TLDR The research cloned keratin 7 genes from humans, mice, and marsupials, found similarities between human and mouse genes, and discovered new areas of K7 expression in mice.
The study successfully cloned and sequenced the keratin 7 (K7) genes and mRNAs from humans, mice, and the marsupial Potorous tridactylis. It found significant conservation of introns and promoter regions between human and mouse K7 genes, suggesting potential regulatory elements. A polyclonal rabbit antibody specific for murine K7 was developed, revealing K7 expression in various mouse tissues, including previously unreported areas like the gastrointestinal tract and tongue. This research provided a foundation for genetic analysis of K7 in relation to human disorders and facilitated the creation of transgenic mice to study K7 mutations.
38 citations
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October 2001 in “British Journal of Dermatology” Keratin K6irs is a marker for the inner root sheath of hair follicles in mice and humans.
101 citations
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August 2001 in “The Journal of Cell Biology” A new keratin 6 type in mice explains why some mice without certain keratin genes still have normal hair and nails.
287 citations
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July 2001 in “Journal of Cell Science” The study found 65 intermediate filament genes, including new keratins, and suggested updating keratin naming.
77 citations
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March 2000 in “Journal of Investigative Dermatology” 119 citations
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January 2000 in “British Journal of Dermatology” Different parts of the nail express different keratins, showing unique patterns of differentiation.
32 citations
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November 1998 in “Journal of Biological Chemistry” Mouse and human keratin 16 can both form filaments, with differences likely due to the tail domain, not the helical domain.
28 citations
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August 1992 in “Differentiation” A new pair of mouse keratins, 65 kD and 48 kD, are found in specific skin areas and are linked to a unique skin differentiation type.
18 citations
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February 1992 in “Molecular Biology Reports” A specific type II hair keratin was identified and found in hair cortex and tongue cells.
238 citations
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May 1989 in “Journal of Investigative Dermatology”
