Skin-Associated Adipocytes in Skin Barrier Immunity: A Mini-Review

January 2023 in “ Frontiers in Immunology ”

Jingyan Guan, Congxiao Wu, Yunfan He, Feng Lu

skin-associated adipocytes skin barrier immunity cytokines adipokines antimicrobial peptides

Studysummary This review discusses the role of skin-associated adipocytes in modulating skin immune responses and infection, reporting no new experimental results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This mini-review discusses the crucial role of skin-associated adipocytes in skin barrier immunity. These adipocytes, located in the subcutis and dermis, produce cytokines, adipokines, and antimicrobial peptides, which interact with immune cells to influence inflammation and contribute to the skin's immune barrier. The review highlights the interconnectedness of the skin's microbiome and various barriers, noting that dysfunction can lead to skin diseases. Adipocytes are suggested as potential therapeutic agents for inflammatory skin diseases like atopic dermatitis and psoriasis, though their dual nature requires careful management to maximize benefits and minimize pro-inflammatory effects.

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Research cited in this study

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research Adipokines in the Skin and Dermatological Diseases

31 citations , November 2020 in “International journal of molecular sciences”

This review discusses the role of adipokines in skin physiology and pathology, suggesting they may influence skin conditions and diseases through interaction with various skin cell types, but reports no new clinical results.

research Dermal White Adipose Tissue: A Newly Recognized Layer of Skin Innate Defense

49 citations , March 2019 in “Journal of Investigative Dermatology”

This review discusses dermal white adipose tissue's roles in skin immunity, highlighting its antimicrobial function and interactions with other immune cells, but reports no new clinical results.

research Emerging Nonmetabolic Functions of Skin Fat

65 citations , January 2018 in “Nature Reviews Endocrinology”

This review discusses the unique features of dermal white adipose tissue, its interaction with hair follicles, and its role in skin physiology, reporting no new experimental findings.

research Adiponectin Signaling Regulates Lipid Production in Human Sebocytes

32 citations , January 2017 in “PLoS ONE”

This study found that adiponectin significantly enhanced lipid production in human sebaceous glands and may be a potential target for treating conditions with reduced sebum production.

research Sebocytes Differentially Express and Secrete Adipokines

74 citations , October 2015 in “Experimental Dermatology”

This study found that sebocytes in human skin express and secrete certain adipokines, suggesting they might play active roles in skin inflammation rather than just being targets.

research Defining Dermal Adipose Tissue

218 citations , May 2014 in “Experimental Dermatology”

This review explores the evolution and development of skin-associated adipose tissue and proposes new nomenclature for the cells and adipose tissue underlying the reticular dermis, without reporting clinical results.

research Hair Growth-Promoting Effects of Adiponectin In Vitro

22 citations , June 2012 in “Journal of Investigative Dermatology”

This study found that adiponectin promotes hair growth in cultured human hair follicles, suggesting its receptors could be a target for clinical hair growth strategies.

research Leptin and the Skin: A New Frontier

108 citations , July 2009 in “Experimental Dermatology”

This review discusses the role of leptin in skin biology and pathology, highlighting its potential in enhancing skin regeneration, hair cycle progression, and wound healing, but reports no new clinical results.