Adiponectin Signaling Regulates Lipid Production in Human Sebocytes

This study investigated the role of adiponectin in lipid production within human sebaceous glands and sebocytes. It was found that adiponectin receptors were expressed in these cells, and adiponectin increased cell proliferation and significantly upregulated lipid production, as demonstrated by various staining techniques and thin layer chromatography. In three-dimensional cultures, adiponectin treatment markedly enhanced lipid synthesis. The findings suggested that adiponectin played a crucial role in sebaceous gland biology and could be a promising target for managing barrier disorders with decreased sebum production, such as atopic dermatitis and aged skin.