Hydrogel Crosslinking Modulates Macrophages, Fibroblasts, And Their Communication During Wound Healing

    August 2024 in “ Nature Communications ”
    Sergei Butenko, Raji R. Nagalla, Christian F. Guerrero‐Juarez … Wendy F. Liu
    Studysummary This study found that in female mice, softer, lightly crosslinked gelatin-based hydrogels promoted better wound healing with less scarring and inflammation compared to stiffer, heavily crosslinked hydrogels, affecting immune and stromal cell behavior.
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    Research cited in this study 3

    1. Engineering Immunomodulatory Biomaterials to Drive Skin Wounds Toward Regenerative Healing Cold Spring Harbor Perspectives in Biology · 2022
    2. Dissecting the Microenvironment Around Biosynthetic Scaffolds in Murine Skin Wound Healing Science Advances · 2021
    3. Activating an Adaptive Immune Response from a Hydrogel Scaffold Imparts Regenerative Wound Healing Nature Materials · 2020