Skin Development And Disease: A Molecular Perspective

July 2024 in “ Current Issues in Molecular Biology ”

Iasonas Dermitzakis, Despoina Chatzi, Stella Aikaterini Kyriakoudi, Nikolaos Evangelidis, Efstratios Vakirlis, Soultana Meditskou, Paschalis Theotokis, Maria Eleni Μanthou

epidermis hair follicles sweat glands signalling pathways skin disorders skin cancers molecular mechanisms

Studysummary This narrative review explores the molecular mechanisms driving skin development and their role in skin diseases, emphasizing how disruptions in these pathways can lead to conditions like congenital disorders and cancers, potentially guiding new targeted therapies.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Molecular and Spatial Landmarks of Early Mouse Skin Development

10 citations , August 2023 in “Developmental cell”

In this study, researchers used advanced techniques to map the early embryonic development of mouse skin, identifying diverse cell populations and uncovering complex interactions essential for skin structure, signaling, and function.

research Developmentally Regulated Expression of Integrin Alpha-6 Distinguishes Neural Crest Derivatives in the Skin

5 citations , May 2023 in “Frontiers in Cell and Developmental Biology”

This study used single-cell techniques and lineage tracing to reveal that integrin α6 expression in neural crest cells can differentiate them into Schwann cells, melanocytes, and fibroblasts in skin, identifying integrin α6 as a potential marker for these derivatives.

research Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases

6 citations , August 2022 in “International Journal of Molecular Sciences”

This review summarizes the role of Ectodysplasin A signaling in skin appendage development and various diseases, noting potential clinical applications but reporting no new research findings.

research Non-Invasive Human Skin Transcriptome Analysis Using mRNA in Skin Surface Lipids

10 citations , March 2022 in “Communications biology”

In this study, researchers found that non-invasive analysis of skin surface lipid RNAs revealed alterations in gene expression patterns associated with atopic dermatitis, suggesting its potential for understanding skin disease pathophysiology.

research Parallels in Signaling Between Development and Regeneration in Ectodermal Organs

8 citations , January 2022 in “Current topics in developmental biology/Current Topics in Developmental Biology”

research Building and Maintaining the Skin

22 citations , October 2021 in “Cold Spring Harbor Perspectives in Biology”

This review discusses the interactions and signals affecting skin stem cells and their environments but reports no new experimental results; the authors highlight the need for understanding these processes to enhance tissue rejuvenation and repair.

research The Dynamics of the Skin’s Immune System

306 citations , April 2019 in “International Journal of Molecular Sciences”

This review discusses the protective roles of skin-resident immune cells in maintaining tissue homeostasis and facilitating wound healing, but reports no new experimental findings.

research From Neural Crest Cells to Melanocytes: Cellular Plasticity During Development and Beyond

66 citations , March 2019 in “Cellular and Molecular Life Sciences”

This review discusses melanocyte development, emphasizing the plasticity of melanoblasts and the role of both intrinsic and extracellular signals in their differentiation and migration, with no new clinical results reported.

research Type XVII Collagen Coordinates Proliferation in the Interfollicular Epidermis

124 citations , July 2017 in “eLife”

This study found that COL17 deficiency in neonatal mice causes abnormal skin cell proliferation due to disrupted Wnt signaling, while replenishing or overexpressing COL17 can reverse this effect in both neonatal and aged skin.

research WNT10A Mutation Causes Ectodermal Dysplasia by Impairing Progenitor Cell Proliferation and KLF4-Mediated Differentiation

96 citations , June 2017 in “Nature Communications”

This study identified WNT10A as crucial for adult epithelial cell proliferation and differentiation, suggesting β-catenin pathway activation may help address regenerative defects in WNT10A mutation patients.

research Notch Signaling Is Significantly Suppressed in Basal Cell Carcinomas and Activation Induces Basal Cell Carcinoma Cell Apoptosis

18 citations , February 2017 in “Molecular Medicine Reports”

This study found that the Notch signaling pathway is suppressed in basal cell carcinomas and highly expressed in hair follicles, suggesting it might be a target for treatment strategies.

research Mutations in KLHL24 Add to the Molecular Heterogeneity of Epidermolysis Bullosa Simplex

44 citations , January 2017 in “Journal of Investigative Dermatology”

This study identified KLHL24 as a new gene linked to a subtype of epidermolysis bullosa simplex, highlighting its role in unresolved cases by involving a degradation-resistant truncated protein impacting keratin turnover.

Mutational Spectrum in 101 Patients with Hypohidrotic Ectodermal Dysplasia and Breakpoint Mapping in Independent Cases of Rare Genomic Rearrangements

research Mutational Spectrum in 101 Patients with Hypohidrotic Ectodermal Dysplasia and Breakpoint Mapping in Independent Cases of Rare Genomic Rearrangements

30 citations , June 2016 in “Journal of Human Genetics”

This study found pathogenic mutations in genes EDA, EDA1R, and EDARADD in 101 out of 124 hypohidrotic ectodermal dysplasia patients, revealing 23 novel mutations and indicating genetic variability.

research Epithelial Skin Biology: Stem Cells and Epidermal Homeostasis

118 citations , January 2016 in “Current Topics in Developmental Biology”

This essay discusses the establishment, maintenance, and role of skin stem cells in tissue homeostasis, wound repair, and their relation to skin cancer, without reporting new experimental findings.

research Molecular Basis of Hypohidrotic Ectodermal Dysplasia: An Update

85 citations , August 2015 in “Journal of Applied Genetics”

This review discusses recent insights into the molecular mechanisms of hypohidrotic ectodermal dysplasia linked to TNFα-related signaling pathway mutations but reports no new experimental results.

research Recently Identified Forms of Epidermolysis Bullosa

39 citations , January 2015 in “Annals of dermatology/Annals of Dermatology”

This review discusses three newly identified forms of epidermolysis bullosa related to mutations in DST-e, EXPH5, and ITGA3, offering insights into their genetic and clinical characteristics but reports no new clinical results.

research BMP-FGF Signaling Axis Mediates Wnt-Induced Epidermal Stratification in Developing Mammalian Skin

84 citations , October 2014 in “PLoS Genetics”

This study found that epidermal Wnt production is crucial for forming the skin's spinous layer through a BMP-FGF signaling cascade, although Wnt from basal cells is not needed for their differentiation.

research Involvement of Wnt, Eda, and Shh at Defined Stages of Sweat Gland Development

55 citations , September 2014 in “Development”

In this study, mouse sweat gland development relied on a regulatory sequence initiated by Wnt/β-catenin signaling, and disruptions in Wnt, Eda, or Shh pathways led to distinct developmental failures.

research Signaling Involved in Hair Follicle Morphogenesis and Development

223 citations , January 2014 in “International Journal of Molecular Sciences”

This article reviews the complex signaling pathways between epithelial and mesenchymal cells crucial for hair follicle morphogenesis, highlighting the Wnt pathway's role as a master regulator without reporting new experimental findings.

research Epidermal Development in Mammals: Key Regulators, Signals from Beneath, and Stem Cells

83 citations , May 2013 in “International Journal of Molecular Sciences”

This review explores embryonic epidermal development and discusses key molecular regulators and roles of the sub-epidermal mesenchyme, but reports no new experimental results.

research Topical Minoxidil Treatment for Congenital Alopecia in Hypohidrotic Ectodermal Dysplasia

12 citations , March 2013

This report describes a case where a 4-year-old boy with congenital alopecia due to hypohidrotic ectodermal dysplasia experienced significant hair growth after using topical minoxidil.

research Skin Melanocytes: Biology and Development

401 citations , January 2013 in “Postepy Dermatologii I Alergologii”

This review discusses the biology and development of skin melanocytes, but reports no new clinical findings.

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

300 citations , August 2012 in “Seminars in Cell & Developmental Biology”

This review discusses mesenchymal–epithelial interactions in hair follicle development and cycling, highlighting recent insights without reporting new experimental results.

research Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair

265 citations , July 2012 in “Cell”

This study found multipotent progenitors in sweat ducts that become unipotent after sweat gland development, highlighting distinct regenerative capabilities in adult glandular skin stem cell populations.

research Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop

138 citations , June 2012 in “Genes & Development”

This study found that dermal Shh signaling regulates specific dermal papilla signatures essential for maintaining hair follicle development, suggesting that the Shh-Noggin signaling loop is crucial for hair morphogenesis.

Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

207 citations , March 2012 in “Development”

In this mouse study, researchers found that dermal Wnt signaling/β-catenin activity is essential for fibroblast proliferation and initiating hair follicle formation by interacting with epidermal Wnt ligands.

research Stem Cells in Embryonic Skin Development

43 citations , January 2012 in “Biological Research”

This review discusses the embryonic origins and characteristics of various stem cell populations in the skin, but it provides no new experimental results.

research Dynamic Signals for Hair Follicle Development and Regeneration

60 citations , July 2011 in “Stem Cells and Development”

This review discusses recent findings on hair follicle morphogenesis and regeneration, focusing on molecular signals and stem cells, and suggests that understanding these processes may aid in developing new strategies for wound healing.

research Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells

283 citations , February 2011 in “Cell stem cell”

COL17A1 is crucial for preventing hair graying and loss by supporting hair and pigment stem cells.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

This study found that in mice, inactivating beta-catenin in the dermal papilla reduces hair follicle progenitor proliferation and disrupts the hair cycle.

research Epidermolysis Bullosa Simplex: A Paradigm for Disorders of Tissue Fragility

189 citations , July 2009 in “The Journal of clinical investigation/The journal of clinical investigation”

This review discusses how research on keratin biology has enhanced the understanding of epidermolysis bullosa simplex and indicates potential new therapeutic approaches, but it presents no new experimental results.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

This review explores how adult skin epithelia preserve stem cell populations for hair follicle regeneration and wound healing, but reports no new experimental results.

research Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle

55 citations , September 2003 in “Experimental Dermatology”

In this study, researchers found that certain cytokines can significantly down-regulate PDGF expression in dermal papilla cells and follicular keratinocytes, indicating a potential link between PDGF signaling and catagen induction.

research Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin

81 citations , January 2003 in “The FASEB Journal”

This study found that follistatin and activin interactions are important for hair follicle development and cycling in mice, suggesting that they may regulate processes involving BMP-2 and its antagonist.

research Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development

318 citations , October 1998 in “The Journal of Cell Biology”

This study found that ectopic expression of the lymphoid-enhancer factor can induce K17 protein in the skin, suggesting a link between skin development and wound repair processes in mice.

research Apoptosis in Human Skin Development: Morphogenesis, Periderm, and Stem Cells

253 citations , March 1994 in “Developmental dynamics”

This study suggests that programmed cell death plays a crucial role in shaping the structure of the human epidermis and its appendages during development.

research The Secret Life of the Hair Follicle

745 citations , February 1992 in “Trends in genetics”

This article describes the potential role of various growth factors and molecules in regulating mammalian hair follicle development but does not present new experimental results.