Notch Signaling Is Significantly Suppressed in Basal Cell Carcinomas and Activation Induces Basal Cell Carcinoma Cell Apoptosis

    February 2017 in “ Molecular Medicine Reports ”
    Fang Shi, Man Yu, David Zloty … Kevin J. McElwee
    Studysummary This study found that the Notch signaling pathway is suppressed in basal cell carcinomas and highly expressed in hair follicles, suggesting it might be a target for treatment strategies.
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    Research cited in this study 4

    1. Hair Follicle Stem Cells: In Vitro and In Vivo Neural Differentiation World journal of stem cells · 2015
    2. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    3. Basal Cell Carcinomas in Mice Arise from Hair Follicle Stem Cells and Multiple Epithelial Progenitor Populations Journal of Clinical Investigation · 2011
    4. Activation of the Transcription Factor Gli1 and the Sonic Hedgehog Signaling Pathway in Skin Tumors Nature · 1997