TLDR EDA signaling is linked to skin disorders, various cancers, and liver disease.
The document discusses the role of Ectodysplasin A (EDA) signaling in various diseases. EDA signaling, initially identified as a regulator of skin appendage formation, is implicated in hypohidrotic ectodermal dysplasia (HED), various types of cancer, and nonalcoholic fatty liver disease (NAFLD). Mutations in EDA can cause HED, a congenital hereditary disease characterized by malformation of skin appendages. In cancer, EDA and its receptors can influence cell proliferation, apoptosis, differentiation, and migration, potentially affecting tumorigenesis and cancer progression. EDA signaling has also been implicated in the pathogenesis of NAFLD and type II diabetes by regulating glucose and lipid metabolism. The document concludes by highlighting the need for further studies on the molecular mechanism and distinct roles of EDA signaling in numerous diseases.
4 citations,
July 2020 in “Biochemical and Biophysical Research Communications” A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.
8 citations,
August 2019 in “Journal of The American Academy of Dermatology” Early diagnosis and treatment, like topical minoxidil, can prevent hair loss in children.
18 citations,
August 2015 in “Biochemical and Biophysical Research Communications” XEDAR triggers a specific signaling pathway in cells.
55 citations,
October 2014 in “Development” Wnt, Eda, and Shh pathways are crucial for different stages of sweat gland development in mice.
30 citations,
June 2014 in “Seminars in Immunology” Future research on ectodysplasin should explore its role in diseases, stem cells, and evolution, and continue developing treatments for genetic disorders like hypohidrotic ectodermal dysplasia.
82 citations,
September 2008 in “Journal of Investigative Dermatology” EDA2R gene linked to hair loss.
43 citations,
February 2013 in “Developmental dynamics” Foxi3 expression in developing teeth and hair is controlled by the ectodysplasin pathway.
30 citations,
June 2014 in “Seminars in Immunology” Future research on ectodysplasin should explore its role in diseases, stem cells, and evolution, and continue developing treatments for genetic disorders like hypohidrotic ectodermal dysplasia.
71 citations,
February 2020 in “Journal of Translational Medicine” Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.
9 citations,
March 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” Ectodysplasin signaling is crucial for skin appendage development, requiring specific doses and durations.
48 citations,
January 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” Chemokine signaling is important for hair development.
