Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases

August 2022 in “ International Journal of Molecular Sciences ”

Ruihan Yang, Yilan Mei, Ye Jiang, Huiling Li, Ruixi Zhao, Jian Sima, Yuyuan Yao

Ectodysplasin A EDA signaling hypohidrotic ectodermal dysplasia HED skin appendage formation mutations in EDA cell proliferation apoptosis differentiation migration tumorigenesis cancer progression glucose metabolism lipid metabolism

Studysummary This review summarizes the role of Ectodysplasin A signaling in skin appendage development and various diseases, noting potential clinical applications but reporting no new research findings.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document discusses the role of Ectodysplasin A (EDA) signaling in various diseases. EDA signaling, initially identified as a regulator of skin appendage formation, is implicated in hypohidrotic ectodermal dysplasia (HED), various types of cancer, and nonalcoholic fatty liver disease (NAFLD). Mutations in EDA can cause HED, a congenital hereditary disease characterized by malformation of skin appendages. In cancer, EDA and its receptors can influence cell proliferation, apoptosis, differentiation, and migration, potentially affecting tumorigenesis and cancer progression. EDA signaling has also been implicated in the pathogenesis of NAFLD and type II diabetes by regulating glucose and lipid metabolism. The document concludes by highlighting the need for further studies on the molecular mechanism and distinct roles of EDA signaling in numerous diseases.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

Ectodysplasin-A2 Induces Dickkopf 1 Expression in Human Balding Dermal Papilla Cells Overexpressing the Ectodysplasin A2 Receptor

research Ectodysplasin-A2 Induces Dickkopf 1 Expression in Human Balding Dermal Papilla Cells Overexpressing the Ectodysplasin A2 Receptor

4 citations , July 2020 in “Biochemical and Biophysical Research Communications”

This study suggests that EDA-A2 induces apoptosis in hair follicles by increasing DKK-1 expression, implicating EDA2R signaling as a potential therapeutic target for androgenetic alopecia.

research Pediatric Androgenetic Alopecia: A Review

8 citations , August 2019 in “Journal of The American Academy of Dermatology”

This study found that androgenetic alopecia is a significant yet under-recognized cause of hair loss in children and adolescents, often linked to family history and typically diagnosed by clinical examination.

research XEDAR Activates the Non-Canonical NF-κB Pathway

18 citations , August 2015 in “Biochemical and Biophysical Research Communications”

This study found that the XEDAR receptor can activate the non-canonical NF-kB pathway involving p100 processing, which is regulated by interactions with TRAF proteins and specific kinases.

research Involvement of Wnt, Eda, and Shh at Defined Stages of Sweat Gland Development

55 citations , September 2014 in “Development”

In this study, mouse sweat gland development relied on a regulatory sequence initiated by Wnt/β-catenin signaling, and disruptions in Wnt, Eda, or Shh pathways led to distinct developmental failures.

research Ectodysplasin Research: Where to Next?

30 citations , June 2014 in “Seminars in Immunology”

This review discusses recent advances in understanding the Eda pathway's role in developmental biology, and highlights ongoing trials and areas for further research, including Eda's potential involvement in cell processes and disease.

research EDA2R Is Associated With Androgenetic Alopecia

82 citations , April 2008 in “Journal of Investigative Dermatology”

EDA2R gene linked to hair loss.