Ectodysplasin Research: Where to Next?

    June 2014 in “ Seminars in Immunology ”
    Sylvie Lefebvre, Marja L. Mikkola
    Studysummary This review discusses recent advances in understanding the Eda pathway's role in developmental biology, and highlights ongoing trials and areas for further research, including Eda's potential involvement in cell processes and disease.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 14

    1. Genotype-Phenotype Correlation in Boys with X-Linked Hypohidrotic Ectodermal Dysplasia American Journal of Medical Genetics · 2014
    2. Expression of Foxi3 Is Regulated by Ectodysplasin in Skin Appendage Placodes Developmental dynamics · 2013
    3. Identification of Ectodysplasin Target Genes Reveals the Involvement of Chemokines in Hair Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2012
    4. WNT10A Mutations Are a Frequent Cause of a Broad Spectrum of Ectodermal Dysplasias with Sex-Biased Manifestation Pattern in Heterozygotes American journal of human genetics · 2009
    5. Recent Positive Selection of a Human Androgen Receptor/Ectodysplasin A2 Receptor Haplotype and Its Relationship to Male Pattern Baldness Human Genetics · 2009
    6. Enhanced Ectodysplasin-A Receptor Signaling Alters Multiple Fiber Characteristics to Produce the East Asian Hair Form Human mutation · 2008
    7. TNF Superfamily in Skin Appendage Development Cytokine & growth factor reviews · 2008
    8. Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes Developmental biology · 2008
    9. EDA2R Is Associated With Androgenetic Alopecia Journal of Investigative Dermatology · 2008
    10. Significant Correction of Disease After Postnatal Administration of Recombinant Ectodysplasin A in Canine X-Linked Ectodermal Dysplasia American Journal of Human Genetics · 2007
    11. Involvement of the Edar Signaling in the Control of Hair Follicle Involution (Catagen) ˜The œAmerican journal of pathology · 2006
    12. Myodegeneration in EDA-A2 Transgenic Mice Is Prevented by XEDAR Deficiency Molecular and Cellular Biology · 2004
    13. Stimulation of Ectodermal Organ Development by Ectodysplasin-A1 Developmental Biology · 2003
    14. Edar/Eda Interactions Regulate Enamel Knot Formation in Tooth Morphogenesis Development · 2000