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    Glossary Ectodysplasin A

    regulates development of skin, hair, teeth, and sweat glands

    Ectodysplasin A (Eda) is a protein crucial for the development of ectodermal tissues, which include skin, hair, teeth, and sweat glands. Mutations in the EDA gene can lead to ectodermal dysplasias, a group of disorders characterized by abnormalities in these tissues, often resulting in sparse hair, missing teeth, and reduced ability to sweat.

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    Research 10 of 320

    1. Stimulation of ectodermal organ development by Ectodysplasin-A1 Developmental Biology · 2003 · 249 citations
    2. Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes Developmental biology · 2008 · 117 citations
    3. Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form Human mutation · 2008 · 98 citations
    4. Expression of <i>Foxi3</i> is regulated by ectodysplasin in skin appendage placodes Developmental dynamics · 2013 · 43 citations
    5. Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness Human Genetics · 2009 · 42 citations
    6. Ectodysplasin Signaling in Cutaneous Appendage Development: Dose, Duration, and Diversity 2009 · 9 citations
    7. Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases International Journal of Molecular Sciences · 2022 · 6 citations
    8. Hypohidrotic Ectodermal Dysplasia with c.28delG Mutation in Ectodysplasin A Gene and Severe Atopic Dermatitis Treated Successfully with Tofacitinib Acta Dermato Venereologica · 2020 · 4 citations
    9. Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor Biochemical and Biophysical Research Communications · 2020 · 4 citations
    10. X-linked Recessive Ectodysplasin A Mutations Induced Hypohidrotic Ectodermal Dysplasia and Severe Atopic Dermatitis Successfully Treated with Dupilumab Acta Dermato Venereologica · 2026
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