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    Glossary Ectodysplasin A

    regulates development of skin, hair, teeth, and sweat glands

    Ectodysplasin A (Eda) is a protein crucial for the development of ectodermal tissues, which include skin, hair, teeth, and sweat glands. Mutations in the EDA gene can lead to ectodermal dysplasias, a group of disorders characterized by abnormalities in these tissues, often resulting in sparse hair, missing teeth, and reduced ability to sweat.

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    Research 30 of 318

    1. Stimulation of ectodermal organ development by Ectodysplasin-A1 Developmental Biology · 2003 · 249 citations
    2. Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes Developmental biology · 2008 · 117 citations
    3. Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form Human mutation · 2008 · 98 citations
    4. Expression of <i>Foxi3</i> is regulated by ectodysplasin in skin appendage placodes Developmental dynamics · 2013 · 43 citations
    5. Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness Human Genetics · 2009 · 42 citations
    6. Ectodysplasin Signaling in Cutaneous Appendage Development: Dose, Duration, and Diversity 2009 · 9 citations
    7. Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases International Journal of Molecular Sciences · 2022 · 6 citations
    8. Hypohidrotic Ectodermal Dysplasia with c.28delG Mutation in Ectodysplasin A Gene and Severe Atopic Dermatitis Treated Successfully with Tofacitinib Acta Dermato Venereologica · 2020 · 4 citations
    9. Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor Biochemical and Biophysical Research Communications · 2020 · 4 citations
    10. X-linked Recessive Ectodysplasin A Mutations Induced Hypohidrotic Ectodermal Dysplasia and Severe Atopic Dermatitis Successfully Treated with Dupilumab Acta Dermato Venereologica · 2026
    11. Ectodysplasin-A (EDA) Signaling Cross-Talk in Skeletogenesis Calcified Tissue International · 2026
    12. Significant Correction of Disease after Postnatal Administration of Recombinant Ectodysplasin A in Canine X-Linked Ectodermal Dysplasia American Journal of Human Genetics · 2007 · 109 citations
    13. Increased expression of Ectodysplasin A2 Receptor EDA2R is the most remarkable and ubiquitous aging-related transcriptional hallmark Research Square (Research Square) · 2021 · 3 citations
    14. Coordinating the Sculptors: Ectodysplasin-A (EDA) Signaling Cross-Talk with Skeletogenic Pathways Preprints.org · 2025
    15. Feather arrays are patterned by interacting signalling and cell density waves PLoS Biology · 2019 · 133 citations
    16. A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia Human genetics · 2008 · 89 citations
    17. TNF superfamily in skin appendage development Cytokine & growth factor reviews · 2008 · 86 citations
    18. Ectodysplasin research—Where to next? Seminars in Immunology · 2014 · 30 citations
    19. Genetic and molecular aspects of androgenetic alopecia Indian Journal of Dermatology, Venereology and Leprology · 2018 · 24 citations
    20. Molecular cloning,sequence analysis and expression of goat Edagene Journal of Northwest A & F University · 2012
    21. Genetics of Alopecia Encyclopedia of Life Sciences · 2012
    22. Ancient lineages of the keratin-associated protein (KRTAP) genes and their co- option in the evolution of the hair follicle Research Square (Research Square) · 2022
    23. Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation Development · 2012 · 207 citations
    24. A review of genetic researches of and rogenic alopecia Int J Genet · 2016
    25. Epidermal patterning and induction of different hair types during mouse embryonic development Birth defects research · 2009 · 81 citations
    26. Dynamic Signals for Hair Follicle Development and Regeneration Stem Cells and Development · 2011 · 60 citations
    27. Transcriptome Reveals Long Non-coding RNAs and mRNAs Involved in Primary Wool Follicle Induction in Carpet Sheep Fetal Skin Frontiers in physiology · 2018 · 37 citations
    28. p53‐dependent transcriptional regulation of EDA2R and its involvement in chemotherapy‐induced hair loss FEBS Letters · 2010 · 37 citations
    29. Genotype-phenotype correlation in boys with X-linked hypohidrotic ectodermal dysplasia American Journal of Medical Genetics · 2014 · 35 citations
    30. EDA and EDAR expression at different stages of hair follicle development in cashmere goats and effects on expression of related genes 2020 · 12 citations