Developmentally Regulated Expression of Integrin Alpha-6 Distinguishes Neural Crest Derivatives in the Skin

    May 2023 in “ Frontiers in Cell and Developmental Biology ”
    Shize Ma, Xiu Li, Rui Cao … Zhigang Yang
    Studysummary This study used single-cell techniques and lineage tracing to reveal that integrin α6 expression in neural crest cells can differentiate them into Schwann cells, melanocytes, and fibroblasts in skin, identifying integrin α6 as a potential marker for these derivatives.
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    Research cited in this study 5

    1. CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2019
    2. Dermal Fibroblasts in Cutaneous Development and Healing Wiley Interdisciplinary Reviews-Developmental Biology · 2017
    3. EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling Cell Reports · 2016
    4. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    5. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007