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GlossaryCD49f (Integrin alpha-6)

protein aiding cell adhesion and migration, crucial for tissue maintenance

CD49f, also known as Integrin alpha-6 or ITGA6, is a protein found on the surface of certain cells that helps them stick to their surroundings. It plays a crucial role in cell adhesion, migration, and signaling, which are important for processes like wound healing and the maintenance of tissues, including hair follicles.

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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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research Highly Upregulated Lhx2 in the Foxn1−/− Nude Mouse Phenotype Reflects a Dysregulated and Expanded Epidermal Stem Cell Niche

6 citations , May 2013 in “PloS one”

The Foxn1(-/-) nude mouse shows disrupted and expanded skin stem cell areas due to high Lhx2 levels.

research Hair Follicular Expression of Integrin Alpha-6 Subunit and p63 in Hair Loss

January 2008 in “Journal of Clinical Dermatology”

Integrin alpha-6 and p63 proteins may play a role in hair loss and are important for hair growth and maintenance.

research Developmentally Regulated Expression of Integrin Alpha-6 Distinguishes Neural Crest Derivatives in the Skin

5 citations , May 2023 in “Frontiers in Cell and Developmental Biology”

Integrin α6 helps identify different neural crest cell types in the skin.

research Transcriptional Profiling of Putative Human Epithelial Stem Cells

16 citations , July 2008 in “BMC Genomics”

Alpha 6 + /MHCI - cells have stem cell traits and are similar to mouse hair follicle stem cells.

research Targeting Integrin Pathways: Mechanisms and Advances in Therapy

54 citations , January 2023 in “Signal Transduction and Targeted Therapy”

New therapies are being developed that target integrin pathways to treat various diseases.

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