Integrin α3β1 in Hair Bulge Stem Cells Modulates CCN2 Expression and Promotes Skin Tumorigenesis

    May 2020 in “ Life science alliance ”
    Veronika Ramovs, Ana Krotenberg García, Ji‐Ying Song … Arnoud Sonnenberg
    Studysummary This study found that epidermal-specific deletion of integrin α3β1 significantly reduces papilloma formation in a skin carcinogenesis model by modulating HB stem cell behavior and CCN2 expression.
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    Research cited in this study 15

    1. Hair Follicle Regeneration Suppresses Ras-Driven Oncogenic Growth Journal of Cell Biology · 2019
    2. Lgr5+ Stem Cells and Their Progeny in Mouse Epidermis Under Regimens of Exogenous Skin Carcinogenesis, and Their Absence in Ensuing Skin Tumors Oncotarget · 2016
    3. Immunohistochemical Expression of Cytokeratin 15, Cytokeratin 19, Follistatin, and Bmi-1 in Basal Cell Carcinoma International Journal of Dermatology · 2015
    4. Hair Follicle and Interfollicular Epidermal Stem Cells Make Varying Contributions to Wound Regeneration Cell Cycle · 2015
    5. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    6. Stem Cell Dynamics in the Hair Follicle Niche Seminars in Cell & Developmental Biology · 2013
    7. CCN2 Modulates Hair Follicle Cycling in Mice Molecular Biology of the Cell · 2013
    8. Epithelial Stem Cells And Implications For Wound Repair Seminars in Cell & Developmental Biology · 2012
    9. A Keratin 15 Containing Stem Cell Population From the Hair Follicle Contributes to Squamous Papilloma Development in the Mouse Molecular Carcinogenesis · 2012
    10. Reassessing K15 as an Epidermal Stem Cell Marker Stem Cell Reviews and Reports · 2011
    11. Hedgehog Signaling Maintains Hair Follicle Stem Cell Phenotype in Young and Aged Human Skin Aging Cell · 2009
    12. Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation Cancer research · 2009
    13. CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice Cancer Research · 2007
    14. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    15. α3β1-Integrin Regulates Hair Follicle But Not Interfollicular Morphogenesis in Adult Epidermis Journal of Cell Science · 2003