Tissue-Engineering Approaches to Enhance Nerve Regeneration During Wound Healing

March 2006 in “ The FASEB Journal ”

François Berthod

nerve regeneration collagen sponge laminin A-Beta nerve fibers A-Delta nerve fibers immature hair follicles nerve fiber migration

TLDR Two methods improved nerve regeneration and touch recovery in skin grafts for burn patients.

The study investigated two tissue-engineering approaches to enhance nerve regeneration in reconstructed skin grafts on mice, aiming to improve tactile recovery for burn patients. The first approach involved a collagen sponge enriched with laminin, which increased nerve fibers by 5 times and improved sensory function in A-Beta and A-Delta nerve fibers. The second approach incorporated immature hair follicles from mouse embryos, leading to nerve fiber migration around the follicles within 30 days. Both methods showed potential in promoting better tactile recovery in patients with deep burns.

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