Tissue-Engineering Approaches to Enhance Nerve Regeneration During Wound Healing

The study investigated two tissue-engineering approaches to enhance nerve regeneration in reconstructed skin grafts on mice, aiming to improve tactile recovery for burn patients. The first approach involved a collagen sponge enriched with laminin, which significantly increased nerve fiber presence and improved sensory function, particularly in A-Beta and A-Delta nerve fibers. The second approach incorporated immature hair follicles from mouse embryos, which promoted nerve fiber migration around the follicles within 30 days. Both methods showed potential in enhancing nerve regeneration and tactile recovery in skin grafts for burn patients.