Recent Advances in the Role of Neuroregulation in Skin Wound Healing

November 2024 in “ Burns & Trauma ”

Abdullah Al Mamun, Chuxiao Shao, Peiwu Geng, Shuanghu Wang, Jian Xiao

neuroregulation skin wound healing nervous system neurotransmitters neuropeptides inflammation angiogenesis cell proliferation peripheral nervous system bioelectronic techniques neuromodulation techniques neuroimmune axis diabetic conditions immune responses cellular communication

Studysummary This review highlights the critical role of neuroregulation in skin wound healing, emphasizing how neurotransmitters and neuropeptides regulate inflammation, angiogenesis, and cell proliferation, and discusses potential therapeutic strategies, such as neuromodulation, to enhance these processes.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Recent advances in understanding neuroregulation in skin wound healing emphasize the critical role of the nervous system in tissue repair. Neurotransmitters and neuropeptides are key regulators of inflammation, angiogenesis, and cell proliferation, significantly influencing skin regeneration. The interaction between the peripheral nervous system and skin cells is crucial, with neuroregulatory signals affecting healing phases. Emerging therapeutic strategies, such as bioelectronic and neuromodulation techniques, aim to enhance wound healing by optimizing the neuroimmune axis and modulating inflammation. The study highlights the potential of neuropeptides in improving wound healing, particularly under diabetic conditions, by modulating immune responses and cellular communication. Understanding specific neuropeptides and neurotransmitters' interactions with skin cells is essential for developing effective treatments.

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Research cited in this study

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