Recent Advances in the Role of Neuroregulation in Skin Wound Healing

Recent advances in understanding neuroregulation in skin wound healing emphasize the critical role of the nervous system in tissue repair. Neurotransmitters and neuropeptides are key regulators of inflammation, angiogenesis, and cell proliferation, significantly influencing skin regeneration. The interaction between the peripheral nervous system and skin cells is crucial, with neuroregulatory signals affecting healing phases. Emerging therapeutic strategies, such as bioelectronic and neuromodulation techniques, aim to enhance wound healing by optimizing the neuroimmune axis and modulating inflammation. The study highlights the potential of neuropeptides in improving wound healing, particularly under diabetic conditions, by modulating immune responses and cellular communication. Understanding specific neuropeptides and neurotransmitters' interactions with skin cells is essential for developing effective treatments.