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research Exosomes in Dermatological Research: Unveiling Their Multifaceted Role in Cellular Communication, Healing, and Disease Modulation

January 2025 in “Cosmetics”

This review highlights the multifunctional role of exosomes in dermatology, noting their potential as therapeutic agents for conditions like skin cancers and hair disorders, while also indicating pathogens exploit them for immune evasion.

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

This study investigated how secretions from cultured human hair follicle-derived keratinocytes affect gene expression in human follicle dermal papilla cells to understand their signaling interactions.

research 757 Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication

5 citations , July 2022 in “Journal of Investigative Dermatology”

Aged skin heals slower due to more inflammation and disrupted cell communication.

research Modeling cell–cell communication for immune systems across space and time

20 citations , November 2019 in “Current Opinion in Systems Biology”

This review discusses how recent studies use models and experiments to understand immune system signaling, but it reports no new clinical findings; the authors suggest strategies for improving these models.

research Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations , January 2019 in “International journal of biological sciences”

This study proposes the miR-22-5p-LEF1 axis as a novel pathway that may regulate hair follicle stem cell proliferation.

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Community Join

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community My Theory Of Androgenic Alopecia

16 upvotes 9 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

737 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Causes of hair loss and treatment can be diagnosed in theory and narrowed down person to person... Minoxidil alone works = circulation problem. Finasteride alone works = lymphatic problem. Nothing works = digestive problem.

3 years ago

community Journey against alopecia - Finasteride 3 month

17 upvotes 4 years ago

A 26-year-old man from France started experiencing hair loss in September 2020 and began using finasteride in June 2021, reporting some improvement after three months without side effects. He plans to continue finasteride for a year before considering additional treatments like minoxidil or dermarolling.

community Korean scientists breakthrough in hair regeneration targeting CXXC5 protein and WNT Signaling Pathway

53 upvotes 8 years ago

A potential non-invasive topical treatment targeting the WNT Signaling Pathway for hair regeneration is being researched, with positive results on human hair follicle cells. Current effective treatments for hair loss include Minoxidil, finasteride, and hair transplantation.

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Learn

7 / 801 results

learn Beta Polypeptide

learn Epidermal Growth Factor

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Stem Cell Factor

learn vitamin b2

How does Vitamin B2 support scalp circulation and cellular energy production? Vitamin B2 enhances scalp circulation and energy production by supporting cellular metabolism.

learn Folic acid

How does folic acid support hair follicle health and growth at a cellular level? Folate is required for the DNA synthesis that fast-dividing hair matrix cells depend on, and severe deficiency causes anemia—but no published trial has given folic acid to people with hair loss and measured the result, so a growth effect is a mechanism, not a finding.

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