Research Progress on the Role of Peripheral Nerves in Wound Healing

September 2025 in “ Journal of Zhejiang University (Medical Sciences) ”

Zhiping Zhang, Dianxu Ren, Jessica A. Tang, Shengli Guo

peripheral nerves wound healing inflammation stem cell behavior angiogenesis nerve fibers electroactive hydrogels nerve growth factor NGF immune responses biomaterials vascular regeneration

Studysummary This review highlights how peripheral nerves play key roles in skin wound healing by modulating immune responses, regulating stem cell functions, and promoting vascularization, suggesting potential avenues for therapeutic strategies targeting neuroregulation.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Peripheral nerves are vital in skin wound healing by transmitting signals, regulating inflammation, and influencing stem cell behavior. They also promote angiogenesis, enhancing blood flow and nutrient supply. Regenerating damaged nerve fibers is crucial for restoring functions. Understanding nerve changes during healing can lead to personalized treatments. Current methods like electroactive hydrogels and NGF application show promise but face challenges. Future research should explore nerve regulation of immune responses and stem cell behavior, and develop biomaterials for nerve and vascular regeneration.

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