TLDR Scientists have made progress in understanding hair follicle stem cells, identifying specific genes and markers, and suggesting their use in treating hair and skin conditions.
The document from 2007 summarizes significant progress in the study of hair follicle stem cells, with a focus on the bulge region of human hair follicles, which is rich in stem cells. It details the use of Laser Capture Microdissection to isolate these cells and Affymetrix Genechip microarrays to analyze their gene expression profiles, based on samples from 5 individuals. The study found 21 genes overrepresented and 37 genes underrepresented in bulge cells, with CD200 identified as a positive cell surface marker for these cells. The isolated bulge cells showed higher colony-forming efficiency, indicating successful stem cell enrichment. The review suggests potential applications in regenerative medicine and gene therapy for hair and skin disorders and acknowledges financial support from various foundations and grants. It also notes the importance of understanding both similarities and differences in gene expression between human and mouse bulge cells for hair biology research.
Cited in this study
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550 citations
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December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
92 citations
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December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Human hair follicle stem cells can be isolated using specific markers for potential therapeutic use.
291 citations
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October 2005 in “Proceedings of the National Academy of Sciences of the United States of America” Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.
236 citations
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July 2001 in “Trends in Molecular Medicine” Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.
949 citations
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January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
1010 citations
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August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
124 citations
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April 2000 in “Nature biotechnology”
1113 citations
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August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.
March 2020 in “Central European Journal of Biology” The study found that stem cells and neutrophils are important for regenerating hair follicle structures in mice.
99 citations
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January 2014 in “Nature communications” Scientists created stem cells that can grow hair and skin.
36 citations
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August 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Canine hair follicles have stem cells similar to human hair follicles, useful for studying hair disorders.