MiR-124 Promotes Neural Differentiation in Mouse Bulge Stem Cells by Repressing Ptbp1 and Sox9

November 2018 in “ Journal of cellular physiology ”

Haleh Mokabber, Nowruz Najafzadeh, Mohammad Mohammadzadeh-Vardin

miR-124 hair follicle stem cells HFSCs Ptbp1 Sox9 neural differentiation RT-PCR miR-9 let-7b MAP2 NeuN

TLDR miR-124 helps mouse hair follicle stem cells become nerve cells by blocking Ptbp1 and Sox9.

The study investigated the role of miR-124 in the neural differentiation of hair follicle stem cells (HFSCs) isolated from mouse whisker follicles. It was found that miR-124 and let-7b expression levels significantly increased during neural differentiation. miR-124 targeted and repressed Sox9 and Ptbp1, leading to decreased levels of these proteins. Overexpression of miR-124 resulted in increased expression of neuronal markers MAP2 and NeuN. The findings suggested that miR-124 promotes the differentiation of HFSCs into neuronal cells by targeting Sox9 and Ptbp1.

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