MicroRNAs in Skin Tissue Engineering

May 2015 in “ Advanced drug delivery reviews ”

Keith L. Miller, David Alan Brown, Mohamed M. Ibrahim, Talisha D. Ramchal, Howard Levinson

microRNAs miRNAs skin tissue engineering bioengineered skin equivalents BSEs autologous BSEs allogeneic BSEs gene expression cellular behavior skin development wound healing

Studysummary This review discusses skin tissue engineering and highlights the potential role of microRNAs in improving bioengineered skin equivalents, concluding that further exploration of microRNA targets could address unmet clinical needs. Our plain-language summary of this paper — not a Tressless recommendation.

The document reviewed the role of microRNAs (miRNAs) in skin tissue engineering, highlighting their potential to address the limitations of current bioengineered skin equivalents (BSEs). Traditional BSEs face challenges such as slow generation of autologous BSEs, poor survival of allogeneic BSEs, and physical limitations. miRNAs, small noncoding RNA segments, can regulate gene expression and cellular behavior, offering a sophisticated and customizable approach to enhance skin tissue engineering. The review discussed the anatomy and repair processes of skin, the role of miRNAs in skin development and wound healing, and future directions for integrating miRNAs into skin tissue engineering to create more effective and functional BSEs.

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