Early-Stage Bilayer Tissue-Engineered Skin Substitute Formed by Adult Skin Progenitor Cells Produces an Improved Skin Structure In Vivo

    September 2020 in “ Stem cell research & therapy ”
    Qun Zhang, Jie Wen, Chang Liu … Xunwei Wu
    Studysummary This study concluded that early-stage tissue-engineered skin substitutes, developed using skin progenitor cells, had a better graft efficiency and supported hair follicle formation, which may improve wound healing outcomes.
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    Research cited in this study 12

    1. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    2. Regeneration of Skin Appendages and Nerves: Current Status and Further Challenges Journal of Translational Medicine · 2020
    3. Pre-Aggregation of Scalp Progenitor Dermal and Epidermal Stem Cells Activates the WNT Pathway and Promotes Hair Follicle Formation In Vitro and In Vivo Systems Stem Cell Research & Therapy · 2019
    4. Dissociated Skin Cells Regenerate Hair Follicles in a Microwound: The Punch Assay Experimental Dermatology · 2018
    5. Tissue Engineering of Skin and Regenerative Medicine for Wound Care Burns & Trauma · 2018
    6. The Patch Assay Reconstitutes Mature Hair Follicles by Culture-Expanded Human Cells Regenerative Medicine · 2017
    7. Assembling Composite Dermal Papilla Spheres with Adipose-Derived Stem Cells to Enhance Hair Follicle Induction Scientific Reports · 2016
    8. A Two-Step Culture Method for Efficient Production of Trichogenic Keratinocytes Tissue Engineering Part C-methods · 2015
    9. Advances in Skin Grafting and Treatment of Cutaneous Wounds Science · 2014
    10. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    11. Concise Review: Tissue-Engineered Skin and Nerve Regeneration in Burn Treatment Stem Cells Translational Medicine · 2013
    12. Tissue-Engineered Skin Preserving the Potential of Epithelial Cells to Differentiate into Hair After Grafting Tissue Engineering Part A · 2010