Tissue-Engineered Skin Preserving the Potential of Epithelial Cells to Differentiate into Hair After Grafting

October 2010 in “ Tissue Engineering Part A ”

Danielle Larouche, Kristine Cuffley, Claudie Paquet, Lucie Germain

tissue-engineered skin hair follicle growth epithelial cells hair buds mouse fibroblast-derived dermis epithelial stem cells

TLDR Tissue-engineered skin can support hair growth after grafting, especially with mouse-derived dermis.

The study evaluated the ability of tissue-engineered skin to support hair follicle growth both in vitro and after grafting. It was found that while no hair growth occurred in vitro, hair did grow after grafting in skin constructed from newborn mouse hair buds (HBs) and mouse fibroblast-derived dermis (mD). The study demonstrated that epithelial stem cells maintained their potential to induce hair growth when cultured in a permissive tissue-engineered dermal environment. However, the hair-forming capacity was not observed in tissues composed of human fibroblast-derived dermis (hD) overlaid with HBs. The results indicated that the type of fibroblast-derived dermis used influenced the outcome, with mD supporting hair growth post-grafting.

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