iTRAQ-Based Quantitative Proteomics Revealing the Therapeutic Mechanism of a Medicinal and Edible Formula YH0618 in Reducing Doxorubicin-Induced Alopecia by Targeting Keratins and TGF-β/Smad3 Pathway

June 2024 in “ Heliyon ”

Renkai Li, Mingxia Chen, Danxi Yan, Liang Chen, Man-di Lin, Bohui Deng, Likai Zhuang, Fei Gao, Gph Leung, Jieshu You

YH0618 doxorubicin-induced alopecia keratin 81 keratin 34 keratin 33a Smad3 TGF-β/Smad3 pathway chemotherapy-induced alopecia doxorubicin chemotherapy

TLDR YH0618 helps reduce chemotherapy-induced hair loss by targeting specific proteins and pathways.

The study investigates the therapeutic mechanism of the medicinal and edible formula YH0618 in reducing doxorubicin-induced alopecia using iTRAQ-based quantitative proteomics. Researchers identified 3894 proteins, with significant changes in keratins (Krt33a, Krt33b, Krt34, Krt81) and the TGF-β/Smad3 pathway due to doxorubicin treatment. YH0618 administration reversed these effects, reducing hair loss and promoting hair regrowth in mice. The findings suggest that YH0618 mitigates hair loss by modulating energy metabolism, hormone control, and inflammatory response, providing a foundation for future research on treatments for chemotherapy-induced alopecia.

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