iTRAQ-Based Quantitative Proteomics Revealing the Therapeutic Mechanism of a Medicinal and Edible Formula YH0618 in Reducing Doxorubicin-Induced Alopecia by Targeting Keratins and TGF-β/Smad3 Pathway

June 2024 in “ Heliyon ”

Renkai Li, Mingxia Chen, Danxi Yan, Liang Chen, Man-di Lin, Bohui Deng, Likai Zhuang, Fei Gao, Gph Leung, Jieshu You

YH0618 doxorubicin-induced alopecia keratin 81 keratin 34 keratin 33a Smad3 TGF-β/Smad3 pathway chemotherapy-induced alopecia doxorubicin chemotherapy

TLDR YH0618 helps reduce chemotherapy-induced hair loss by targeting specific proteins and pathways.

YH0618, a medicinal and edible formulation, has shown promise in reducing doxorubicin-induced alopecia by targeting specific proteins and pathways. In a study involving 3894 proteins from mouse skin tissue, doxorubicin treatment upregulated 18 proteins and downregulated one, effects which were reversed by YH0618. Key proteins such as keratin 81, keratin 34, keratin 33a, and Smad3 were identified as potential therapeutic targets. The study's findings suggest that YH0618 mitigates hair loss by modulating these proteins and pathways, offering new insights and potential strategies for treating chemotherapy-induced alopecia.

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research Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway

March 2023 in “International Journal of Molecular Sciences”

research Effect of a Medicinal and Edible Decoction YH0618 on Chemotherapy-Induced Dermatologic Toxicity: A Randomized Controlled Trial

January 2021 in “Annals of translational medicine”

YH0618 helped reduce skin and nail problems and fatigue in chemotherapy patients.

research Association of Inflammation With Progression of Hair Loss in Women With Frontal Fibrosing Alopecia

16 citations, June 2020 in “JAMA dermatology”

More inflammation leads to faster and worse hair loss in women with frontal fibrosing alopecia.

A Medicinal and Edible Formula YH0618 Ameliorates the Toxicity Induced by Doxorubicin via Regulating the Expression of Bax/Bcl-2 and FOXO4

research A Medicinal and Edible Formula YH0618 Ameliorates the Toxicity Induced by Doxorubicin via Regulating the Expression of Bax/Bcl-2 and FOXO4

17 citations, January 2019 in “Journal of cancer”

The formula YH0618 can reduce the harmful side effects of the chemotherapy drug Doxorubicin and protect healthy cells.

research Chemotherapy-Induced Alopecia: The Urgent Need for Treatment Options

4 citations, September 2018 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

There is an urgent need for better treatments for hair loss caused by chemotherapy.

research Pathogenesis and Treatment Options for Chemotherapy-Induced Alopecia: A Systematic Review

34 citations, January 2018 in “International Journal of Dermatology”

Scalp cooling is the most effective FDA-approved method to prevent chemotherapy-induced hair loss, but more research is needed for other treatments.

research A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention

38 citations, September 2017 in “Oncologist”

Scalp cooling can help prevent chemotherapy-induced hair loss with a 50-90% success rate and is safe for patients.

research Differential Expression of Proteins Associated with the Hair Follicle Cycle: Proteomics and Bioinformatics Analyses

10 citations, January 2016 in “PLOS ONE”

Researchers found 44 proteins that change during different hair growth stages and may be important for hair follicle function.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations, February 2013 in “The Lancet Oncology”

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

research Estrogen Leads to Reversible Hair Cycle Retardation Through Inducing Premature Catagen and Maintaining Telogen

42 citations, July 2012 in “PLOS ONE”

Estrogen can temporarily slow down hair growth but this can be reversed.

research Mutations In AEC Syndrome Skin Reveal A Role For p63 In Basement Membrane Adhesion, Skin Barrier Integrity And Hair Follicle Biology

33 citations, May 2012 in “British Journal of Dermatology”

Mutations in the p63 gene affect skin adhesion, barrier integrity, and hair growth.

research Treatment of Chemotherapy-Induced Alopecia

64 citations, July 2011 in “Dermatologic Therapy”

Scalp cooling can prevent chemotherapy-induced hair loss, and certain treatments can speed up hair regrowth, but more research is needed for better treatments.

Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

research Chemotherapy-Induced Alopecia in Mice: Induction by Cyclophosphamide, Inhibition by Cyclosporine A, and Modulation by Dexamethasone

36 citations, April 1994 in “PubMed”

Cyclosporine A slows down hair loss from chemotherapy in mice, while dexamethasone increases hair loss but speeds up regrowth.