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GlossaryKeratin 2 (KRT2)

protein providing structural strength to skin, hair, and nails

Keratin 2 (KRT2) is a type of protein found in the outer layer of the skin, hair, and nails. It plays a crucial role in providing structural strength and resilience to these tissues, helping to protect them from damage and wear. Mutations in the KRT2 gene can lead to skin disorders such as ichthyosis bullosa of Siemens, which is characterized by blistering and scaling of the skin.

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research Screening of Proteins Related to Wool Development and Fineness in Gansu Alpine Fine-Wool Sheep

September 2025 in “Animals”

Key proteins and pathways are crucial for wool fineness, but more research is needed.

research Connecting Signaling Dynamics With Cell Fates In Live Mice

April 2021 in “Journal of Investigative Dermatology”

Stem cells control their future role by changing ERK signal timing, affecting tissue regeneration and cancer.

research Cutaneous Overexpression of Cyclooxygenase-2 Models Androgenetic Alopecia in Adult Mice

April 2021 in “Journal of Investigative Dermatology”

Cyclooxygenase-2 overexpression in mice skin causes hair loss like human androgenetic alopecia.

research Types I and II Keratin Intermediate Filaments

211 citations , April 2018 in “Cold Spring Harbor Perspectives in Biology”

Keratins are crucial for cell structure, growth, and disease risk.

research The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle

87 citations , July 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human beard hair medulla contains a unique and complex mix of keratins not found in other human tissues.

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