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GlossaryKeratin 2 (KRT2)

protein providing structural strength to skin, hair, and nails

Keratin 2 (KRT2) is a type of protein found in the outer layer of the skin, hair, and nails. It plays a crucial role in providing structural strength and resilience to these tissues, helping to protect them from damage and wear. Mutations in the KRT2 gene can lead to skin disorders such as ichthyosis bullosa of Siemens, which is characterized by blistering and scaling of the skin.

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research Transcriptome Sequencing Reveals Key Genes Associated With Hair Follicle Development in Qianhua Mutton Merino

December 2025 in “Frontiers in Veterinary Science”

Key genes like KRT27 and IGF-2 are crucial for hair follicle development in Qianhua Mutton Merino sheep.

research Screening of Proteins Related to Wool Development and Fineness in Gansu Alpine Fine-Wool Sheep

September 2025 in “Animals”

Key proteins and pathways are crucial for wool fineness, but more research is needed.

research Differential Expression of Type I IRS Keratin Genes in Three Breeds of Sheep

January 2012 in “Zhongguo shouyi xuebao”

Sheep breeds show different keratin gene expression in the groin, linked to hair follicle density.

research Connecting Signaling Dynamics With Cell Fates In Live Mice

April 2021 in “Journal of Investigative Dermatology”

Stem cells control their future role by changing ERK signal timing, affecting tissue regeneration and cancer.

research Cutaneous Overexpression of Cyclooxygenase-2 Models Androgenetic Alopecia in Adult Mice

April 2021 in “Journal of Investigative Dermatology”

Cyclooxygenase-2 overexpression in mice skin causes hair loss like human androgenetic alopecia.

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