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Glossary microRNA

small RNA molecules that regulate gene expression by binding mRNA

MicroRNA (miRNA) are small, non-coding RNA molecules, typically about 22 nucleotides long, that play a crucial role in regulating gene expression. They function by binding to complementary sequences on messenger RNA (mRNA) molecules, leading to mRNA degradation or inhibition of translation, thereby controlling various biological processes, including development, differentiation, and disease.

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research Micro‐RNA‐31 controls hair cycle‐associated changes in gene expression programs of the skin and hair follicle

149 citations , June 2010 in “The FASEB journal”

In this study, miR-31 was found to play a significant role in hair cycle regulation in mice by controlling key gene expressions involved in hair growth and differentiation.

research MicroRNA in skin diseases

27 citations , July 2017 in “European Journal of Dermatology”

This article reviews the role of microRNAs as epigenetic modulators in dermatology but reports no new clinical findings.

research Hairless Up‐Regulates Tgf‐β2 Expression via Down‐Regulation of miR‐31 in the Skin of “Hairpoor” (Hr^Hp) Mice

11 citations , January 2015 in “Journal of cellular physiology”

This study suggests that abnormal hair cycles in Hr mutant mice may be caused by HR protein overexpression, which down-regulates miR-31 and increases Tgf-β2 expression.

research 192 MicroRNAs and their regulatory interactions in the human hair follicle

August 2016 in “Journal of Investigative Dermatology”

This study explored the role of nine specific miRNAs in human hair follicles, revealing significant miRNA/mRNA correlations for miR-24, miR-31, and miR-106a and identifying target genes involved in hair biology.

research Exploring molecular mechanisms controlling skin homeostasis and hair growth : microRNAs in hair-cycle-dependent gene regulation, hair growth and associated tissue remodelling

January 2010 in “Bradford Scholars (University of Bradford)”

This study found that microRNAs play key roles in regulating gene expression during the hair cycle in mice, impacting follicle growth and skin homeostasis through mechanisms involving major signalling pathways.

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community Most promising cures for baldness as of May 2026

70 upvotes 3 months ago

PP405 is the most promising future treatment for hair loss, aiming to reactivate dormant hair follicles. Clascoterone 5% is the most promising near-term drug, while current strategies include using finasteride or dutasteride to stabilize hair loss and minoxidil to stimulate growth.

community MicroRNA science breakthrough? Softening stem cells

6 upvotes 3 years ago

A potential breakthrough in hair loss treatment involves softening hair follicle stem cells, but its effectiveness in humans is uncertain. Users express skepticism, noting past successes in mice that haven't translated to human treatments.

community Baldness Breakthrough: microRNA Stimulates Hair Growth in Aging Follicles

316 upvotes 3 years ago

miR-205, a tiny RNA, can stimulate hair growth by softening aging hair follicle stem cells in mice. Future tests aim to see if this can work in humans.

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