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Glossary microRNA

small RNA molecules that regulate gene expression by binding mRNA

MicroRNA (miRNA) are small, non-coding RNA molecules, typically about 22 nucleotides long, that play a crucial role in regulating gene expression. They function by binding to complementary sequences on messenger RNA (mRNA) molecules, leading to mRNA degradation or inhibition of translation, thereby controlling various biological processes, including development, differentiation, and disease.

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research Micro‐RNA‐31 controls hair cycle‐associated changes in gene expression programs of the skin and hair follicle

149 citations , June 2010 in “The FASEB journal”

In this study, miR-31 was found to play a significant role in hair cycle regulation in mice by controlling key gene expressions involved in hair growth and differentiation.

research MicroRNA in skin diseases

27 citations , July 2017 in “European Journal of Dermatology”

This article reviews the role of microRNAs as epigenetic modulators in dermatology but reports no new clinical findings.

research Hairless Up‐Regulates Tgf‐β2 Expression via Down‐Regulation of miR‐31 in the Skin of “Hairpoor” (Hr^Hp) Mice

11 citations , January 2015 in “Journal of cellular physiology”

This study suggests that abnormal hair cycles in Hr mutant mice may be caused by HR protein overexpression, which down-regulates miR-31 and increases Tgf-β2 expression.

research 192 MicroRNAs and their regulatory interactions in the human hair follicle

August 2016 in “Journal of Investigative Dermatology”

This study explored the role of nine specific miRNAs in human hair follicles, revealing significant miRNA/mRNA correlations for miR-24, miR-31, and miR-106a and identifying target genes involved in hair biology.

research Exploring molecular mechanisms controlling skin homeostasis and hair growth : microRNAs in hair-cycle-dependent gene regulation, hair growth and associated tissue remodelling

January 2010 in “Bradford Scholars (University of Bradford)”

This study found that microRNAs play key roles in regulating gene expression during the hair cycle in mice, impacting follicle growth and skin homeostasis through mechanisms involving major signalling pathways.

research Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats

2 citations , July 2025 in “Frontiers in Veterinary Science”

This review highlights that microRNAs (miRNAs) play crucial roles in hair follicle development and cycling in cashmere goats, detailing recent advances in understanding their regulatory functions and potential applications in improving cashmere fiber quality and diagnosing hair disorders.

research Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer

December 2023 in “Animals”

In this study, researchers analyzed miRNA and gene expression in the hair follicles of FMD during different hair cycle stages, identifying differential expression patterns and key pathways involved in hair follicle development and growth.

research The functions of ocu-miR-205 in regulating hair follicle development in Rex rabbits

April 2020

This study found that ocu-miR-205 promotes the apoptosis of dermal papilla cells and the transformation of hair follicles from growth to regression and resting phases in Rex rabbits.

research Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

106 citations , March 2013 in “Nature Communications”

This study found several microRNA-related genetic variants linked to epithelial ovarian cancer risk, with a notable association at the 17q21.31 region, suggesting potential new susceptibility genes.

research Association of single nucleotide polymorphisms in the RAB5B gene 3′UTR region with polycystic ovary syndrome in Chinese Han women

11 citations , April 2019 in “Bioscience Reports”

In this study, single nucleotide polymorphisms in the RAB5B gene were linked to an increased risk of polycystic ovary syndrome and associated with specific microRNA binding sites.

research Identification of microRNAs involved in growth arrest and cell death in hydrogen peroxide-treated human dermal papilla cells

12 citations , April 2014 in “Molecular Medicine Reports”

In this study, transcriptome analysis identified 68 differentially expressed miRNAs in human dermal papilla cells treated with hydrogen peroxide, suggesting they play a significant role in growth arrest and apoptosis.

research Genome-wide detection of RNA editing events during the hair follicles cycle of Tianzhu white yak

October 2022 in “BMC genomics”

This study investigated adenosine-to-inosine RNA editing in the hair follicle cycle of Tianzhu white yak, identifying numerous editing sites and suggesting their involvement in pathways related to hair growth.

MicroRNAs in the Skin: Role in Development, Homeostasis, and Regeneration

research MicroRNAs in the skin: role in development, homoeostasis and regeneration

31 citations , July 2017 in “Clinical Science”

This review discusses the role of microRNAs in skin function and potential therapeutic applications, emphasizing their importance in wound healing and disease management, though it reports no new experimental findings.

research Orchestrated Role of microRNAs in Skin Development and Regeneration

January 2018 in “Contributions to management science”

This review discusses the role of microRNA in skin development and disease, highlighting its potential for novel therapies, and reports no clinical results.

research The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat

13 citations , September 2018 in “Scientific Reports”

In this study, researchers found that microRNAs and specific target genes, such as MiR-195 and genes like CHP1, SMAD2, FZD6, and SIAH1, play significant roles in regulating hair follicle initiation in cashmere goats.

research MiR-23b and miR-133 Cotarget TGFβ2/NOTCH1 in Sheep Dermal Fibroblasts, Affecting Hair Follicle Development

4 citations , March 2024 in “Cells”

This study found that the microRNAs oar-miR-23b and oar-miR-133 inhibit the proliferation and migration of sheep dermal fibroblasts, impacting the development of hair follicles in superfine wool sheep by targeting the genes TGFβ2 and NOTCH1.

research The Molecular Revolution in Cutaneous Biology: Noncoding RNAs: New Molecular Players in Dermatology and Cutaneous Biology

22 citations , April 2017 in “Journal of Investigative Dermatology”

This review highlights recent advances in understanding how non-coding RNAs, particularly miRNAs and lncRNAs, regulate skin development and homeostasis, but reports no new clinical results.

research Integrative analysis reveals ncRNA-mediated molecular regulatory network driving secondary hair follicle regression in cashmere goats

50 citations , March 2018 in “BMC Genomics”

This study expands knowledge of non-coding RNAs in goats and other mammals, enhancing understanding of their roles in hair follicle growth and regression.

research MiR-92a-1-5p and miR-328-3p Are Up-Regulated in Skin of Female Pattern Hair Loss Patients

4 citations , January 2019 in “Annals of Dermatology”

Higher levels of MiR-92a-1-5p and miR-328-3p found in female hair loss patients.

research Interplay of MicroRNA-21 and SATB1 in Epidermal Keratinocytes during Skin Aging

16 citations , June 2019 in “Journal of Investigative Dermatology”

The researchers reported that miR-21 expression increases with age in both human and mouse skin and may contribute to skin aging by targeting the chromatin remodeler SATB1 in keratinocytes.

research RETRACTED ARTICLE: Up-regulated lncRNA5322 elevates MAPK1 to enhance proliferation of hair follicle stem cells as a ceRNA of microRNA-19b-3p

9 citations , June 2019 in “Cell cycle/Cell cycle (Georgetown, Tex. Online)”

A specific RNA increases hair stem cell growth and skin healing by affecting a protein through interaction with a microRNA.

research Analysis of histological and microRNA profiles changes in rabbit skin development

7 citations , January 2020 in “Scientific Reports”

This study identified differentially expressed miRNAs between the telogen and anagen phases of hair growth in Wan Strain Angora rabbits, contributing to understanding miRNA-mediated regulation of rabbit hair follicle cycling.

research Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation

71 citations , January 2019 in “International journal of biological sciences”

This study proposes the miR-22-5p-LEF1 axis as a novel pathway that may regulate hair follicle stem cell proliferation.

research MiR-23b and miR-133 cotarget TGFβ2/NOTCH1 in dermal fibroblasts and affect hair follicle development in sheep

August 2023 in “Research Square (Research Square)”

This study found that two microRNAs, oar-miR-23b and oar-miR-133, inhibit the development of hair follicles in superfine wool sheep by targeting genes involved in key signaling pathways, suggesting their potential use as molecular markers for breeding fine wool sheep.

research Potential Involvement of miR-144 in the Regulation of Hair Follicle Development and Cycle Through Interaction with Lhx2

1 citations , November 2024 in “Genes”

This study suggests that miR-144 influences hair follicle dynamics through its impact on Lhx2, which could lead to advancements in cashmere production, fleece quality, and treatments for hair growth disorders.

research The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics

38 citations , June 2019 in “International Journal of Molecular Sciences”

This review discusses the potential role of extracellular vesicles in modulating hair follicle dynamics and reports no new clinical results; future investigations may inform treatment strategies for skin disorders.

Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit Hair Follicle Cycle by RNA Sequencing

research Systematic Analysis of Non-coding RNAs Involved in the Angora Rabbit (Oryctolagus cuniculus) Hair Follicle Cycle by RNA Sequencing

35 citations , May 2019 in “Frontiers in genetics”

This study reported that specific non-coding RNAs may regulate the hair follicle cycle in Angora rabbits by acting as competitive endogenous RNAs, enhancing understanding of ncRNA roles in hair growth.