The Opioid Receptor Influences Circadian Rhythms in Human Keratinocytes Through the β-Arrestin Pathway

    January 2024 in “ Cells ”
    Paul Bigliardi, Seetanshu Junnarkar, Chinmay Markale … Paul Bigliardi
    Studysummary This study found that activation of delta-opioid receptors in keratinocytes may delay the expression of the PER2 gene, suggesting a possible link to cancer development through circadian rhythm disruption.
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    Research cited in this study 5

    1. Hair Growth Promotion by Delta-Opioid Receptor Activation Biomolecules & Therapeutics · 2021
    2. Skin Cell Heterogeneity in Development, Wound Healing, and Cancer Trends in cell biology · 2018
    3. The Circadian Clock in Skin Journal of Biological Rhythms · 2015
    4. Regulated Proenkephalin Expression in Human Skin and Cultured Skin Cells ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    5. Expression of Mu-Opiate Receptor in Human Epidermis and Keratinocytes Journal of Investigative Dermatology · 1998