TLDR Delta-opioid receptors affect skin cell circadian rhythms, possibly impacting wound healing and cancer.
This study investigates the role of the delta opioid receptor (DOPr) in regulating circadian rhythms in human keratinocytes through the β-arrestin pathway. Activation of DOPr with Met-enkephalin caused a 5.6-hour phase shift in the expression of the PER2 gene and altered the expression of clock-controlled genes DBP and Tef. Mechanistically, DOPr and β-arrestin-1 co-localized in the nucleus, enhancing β-arrestin-1 binding to the PER2 promoter and histone H4 acetylation. DOPr knockdown disrupted PER2 rhythmicity, indicating DOPr's essential role in maintaining circadian rhythms. These findings suggest that DOPr influences circadian regulation and could be a potential target for treating circadian rhythm disorders, skin cancer, and impaired wound healing.
1 citations
,
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211 citations
,
May 2018 in “Trends in cell biology” Different types of skin cells play specific roles in development, healing, and cancer.
127 citations
,
January 2015 in “Journal of Biological Rhythms” The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.
77 citations
,
December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” Human skin cells produce proenkephalin, which changes with environmental factors and skin diseases.
111 citations
,
August 1998 in “Journal of Investigative Dermatology” μ-opiate receptors in skin cells may affect skin health and healing.
1 citations
,
June 2021 in “Biomolecules & Therapeutics” Activating δ-opioid receptors can help hair grow.
140 citations
,
February 2014 in “Neuron” Delta opioid receptors help regulate touch sensation by reducing neurotransmitter release in the spinal cord.
July 2022 in “International journal of KIU” Genetics influence opioid addiction risk, diet affects COVID-19 severity, Aerva lanata may harm kidneys, some plants fight fungi and cancer, and nursing students need better contraceptive knowledge.
October 2020 in “Authorea (Authorea)” Men and women react differently to opioids, with hormones potentially influencing these differences.
26 citations
,
May 2014 in “BioEssays” Using neurohormones to control keratin can lead to new skin disease treatments.
