The Opioid Receptor Influences Circadian Rhythms in Human Keratinocytes Through the β-Arrestin Pathway

January 2024 in “ Cells ”

Paul Bigliardi, Seetanshu Junnarkar, Chinmay Markale, Stanley F. Lo, Elisa Bigliardi, Alex Kalyuzhny, Sheena L. M. Ong, Ray Dunn, Walter Wahli, Paul Bigliardi

delta opioid receptor DOPr Met-enkephalin PER2 gene DBP gene Tef gene β-arrestin pathway β-arrestin-1 histone H4 acetylation circadian rhythms keratinocytes skin cancer wound healing PER2 DBP Tef beta-arrestin pathway beta-arrestin-1

Studysummary This study found that activation of delta-opioid receptors in keratinocytes may delay the expression of the PER2 gene, suggesting a possible link to cancer development through circadian rhythm disruption.

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