Neuroendocrine Controls of Keratin Expression in Human Skin

December 2018 in “ IntechOpen eBooks ”

Yuval Ramot, Ralf Paus

neurohormones neuropeptides keratin expression thyrotropin-releasing hormone thyrotropin opioids prolactin cannabinoid receptor 1-ligands skin homeostasis hair follicle homeostasis skin pathologies TRH TSH CB1 receptor

TLDR Neurohormones help control skin health and could treat skin disorders.

The document reviewed the role of neurohormones and neuropeptides in controlling keratin expression in human skin, highlighting the involvement of thyrotropin-releasing hormone, thyrotropin, opioids, prolactin, and cannabinoid receptor 1-ligands. It suggested that this neuroendocrine regulation is crucial for maintaining skin and hair follicle homeostasis and may play a role in skin pathologies. The review emphasized the need for further exploration in this area and proposed that neurohormones could potentially be used to treat skin disorders characterized by abnormal keratin expression.

View this study on api.intechopen.com →

Discuss this study in the Community →

Cited in this study

33 / 33 results

research Mechanical Forces in Skin Disorders

65 citations , June 2018 in “Journal of Dermatological Science”

Skin problems can be caused or worsened by physical forces and pressure on the skin.

research Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases

80 citations , May 2018 in “Trends in Molecular Medicine”

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

research Melatonin: A Cutaneous Perspective on Its Production, Metabolism, and Functions

185 citations , March 2018 in “Journal of Investigative Dermatology”

Melatonin may benefit skin health and could be a promising treatment in dermatology.

research Evolution of Trichocyte Keratins

18 citations , January 2018 in “Advances in experimental medicine and biology”

Hair keratins evolved from ancient proteins, diversifying through gene changes, crucial for forming claws and later hair in mammals.

research Divergent Proliferation Patterns of Distinct Human Hair Follicle Epithelial Progenitor Niches In Situ and Their Differential Responsiveness to Prostaglandin D2

21 citations , November 2017 in “Scientific Reports”

Different human hair follicle stem cells grow at different rates and respond differently to a baldness-related compound.

research Exploring the Brain-Skin Connection: Leads and Lessons from the Hair Follicle

30 citations , October 2016 in “Current research in translational medicine”

Hair follicles on the scalp interact with and respond to the nervous system, influencing their own behavior and growth.

research A Primer for Studying Cell Cycle Dynamics of the Human Hair Follicle

38 citations , July 2016 in “Experimental Dermatology”

The document concludes that understanding hair follicle cell cycles is crucial for hair growth and alopecia research, and recommends specific techniques and future research directions.

research The Twisting Tale of Woolly Hair: A Trait with Many Causes

18 citations , January 2015 in “Journal of medical genetics”

New genes linked to woolly hair have been found, which could help treat it and change hair texture.

research Molecular Genetics of Alopecias

9 citations , January 2015 in “Current problems in dermatology”

Scientists have found specific genes linked to different hair loss conditions, which could lead to new treatments.

research Neuroendocrinology of the Hair Follicle: Principles and Clinical Perspectives

98 citations , October 2014 in “Trends in Molecular Medicine”

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

research Harnessing Neuroendocrine Controls of Keratin Expression: A New Therapeutic Strategy for Skin Diseases?

26 citations , May 2014 in “BioEssays”

Using neurohormones to control keratin can lead to new skin disease treatments.

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations , March 2014 in “BioEssays”

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

research Thyrotropin-Releasing Hormone Promotes Wound Re-Epithelialisation in Frog and Human Skin

46 citations , September 2013 in “PLOS ONE”

Thyrotropin-Releasing Hormone helps heal wounds in frog and human skin.

research Is Thyrotropin-Releasing Hormone a Novel Neuroendocrine Modulator of Keratin Expression in Human Skin?

10 citations , July 2013 in “British Journal of Dermatology”

Thyrotropin-releasing hormone may help control skin and hair growth and could aid in treating related disorders.

research Tumor Necrosis Factor Alpha, Interferon Gamma, and Substance P Are Novel Modulators of Extrapituitary Prolactin Expression in Human Skin

24 citations , April 2013 in “PLOS ONE”

TNFα, IFNγ, and Substance P significantly affect prolactin levels in human skin, suggesting new treatments for skin and hair conditions.

research The Expanding Significance of Keratin Intermediate Filaments in Normal and Diseased Epithelia

186 citations , February 2013 in “Current opinion in cell biology”

Keratin proteins are increasingly recognized as important for cell health and are linked to many diseases.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations , February 2013 in “The Lancet Oncology”

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

research Utilizing the Hair Follicle to Dissect the Regulation and Autocrine/Paracrine Activities of Prolactin in Humans

12 citations , May 2012 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism”

Human scalp hair follicles can be used to study how prolactin affects hair growth and cell death.

research A Neuroendocrinological Perspective on Human Hair Follicle Pigmentation

56 citations , January 2011 in “Pigment Cell & Melanoma Research”

Brain hormones significantly affect hair color and could potentially be used to prevent or reverse grey hair.

research Prolactin: An Emerging Force Along the Cutaneous–Endocrine Axis

51 citations , September 2010 in “Trends in Endocrinology and Metabolism”

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

research Thyrotropin-Releasing Hormone and Estrogen Differentially Regulate Prolactin and Prolactin Receptor Expression in Female Human Skin and Hair Follicles In Vitro

37 citations , March 2010 in “British Journal of Dermatology”

Oestrogen and thyrotropin-releasing hormone affect prolactin and its receptor in human skin and hair, suggesting new treatment options for related conditions.

research Mind the Gender Gap: Does Prolactin Exert Gender and Site-Specific Effects on the Human Hair Follicle?

36 citations , March 2010 in “Journal of Investigative Dermatology”

Prolactin may affect hair growth differently based on gender and scalp area.

research Prolactin: A Novel Neuroendocrine Regulator of Human Keratin Expression In Situ

64 citations , January 2010 in “The FASEB Journal”

Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.

research Exploring the Thyroid-Skin Connection: Concepts, Questions, and Clinical Relevance

49 citations , January 2010 in “Journal of Investigative Dermatology”

Thyroid function affects skin health, with a complex interaction between the two.

research Thyrotropin Releasing Hormone: A New Player in Human Hair Growth Control

72 citations , October 2009 in “The FASEB journal”

TRH stimulates human hair growth and extends the hair growth phase.

research Prolactin and the Skin: A Dermatological Perspective on an Ancient Pleiotropic Peptide Hormone

98 citations , May 2009 in “Journal of Investigative Dermatology”

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

research Endocrine Controls of Keratin Expression

54 citations , March 2009 in “BioEssays”

Hormones control keratin production in skin and hair.

research Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation

67 citations , February 2009 in “Developmental Biology”

Msx2 and Foxn1 are both crucial for hair growth and health.

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations , November 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

research Epithelial Cells in the Hair Follicle Bulge Do Not Contribute to Epidermal Regeneration After Glucocorticoid-Induced Cutaneous Atrophy

23 citations , December 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicle bulge cells don't help skin regrow after glucocorticoid damage; interfollicular epidermis cells do.

research Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, Which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

128 citations , March 2006 in “American Journal of Pathology”

Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

research Neuroimmunoendocrine Circuitry of the Brain-Skin Connection

293 citations , January 2006 in “Trends in Immunology”

Stress can worsen skin conditions and stop hair growth by affecting the body's stress response system.

research Prolactin and Its Receptor Are Expressed in Murine Hair Follicle Epithelium, Show Hair Cycle-Dependent Expression, and Induce Catagen

91 citations , May 2003 in “American Journal of Pathology”

Prolactin affects hair growth cycles and can cause early hair follicle regression.