Thyrotropin-Releasing Hormone Promotes Wound Re-Epithelialisation in Frog and Human Skin

    September 2013 in “ PLOS ONE ”
    Natalia Meier, Iain S. Haslam, David M. Pattwell … Ralf Paus
    Studysummary This study identified thyrotropin-releasing hormone (TRH) as a stimulant of wound healing in both frog and human skin models, suggesting it as a potential neuroendocrine wound repair promoter.
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    Research cited in this study 10

    1. A Novel Control of Human Keratin Expression: Cannabinoid Receptor 1-Mediated Signaling Down-Regulates the Expression of Keratins K6 and K16 in Human Keratinocytes In Vitro and In Situ PeerJ · 2013
    2. Thyroid-Stimulating Hormone: A Novel, Locally Produced Modulator of Human Epidermal Functions, Regulated by Thyrotropin-Releasing Hormone and Thyroid Hormones Endocrinology · 2010
    3. Exploring the Thyroid-Skin Connection: Concepts, Questions, and Clinical Relevance Journal of Investigative Dermatology · 2009
    4. Thyrotropin Releasing Hormone: A New Player in Human Hair Growth Control ˜The œFASEB journal · 2009
    5. Methods in Hair Research: How to Objectively Distinguish Between Anagen and Catagen in Human Hair Follicle Organ Culture Experimental Dermatology · 2009
    6. Exploring the Role of Stem Cells in Cutaneous Wound Healing Experimental Dermatology · 2009
    7. Human Female Hair Follicles Are a Direct, Nonclassical Target for Thyroid-Stimulating Hormone Journal of Investigative Dermatology · 2008
    8. Delayed Wound Healing in Keratin 6a Knockout Mice Molecular and Cellular Biology · 2000
    9. The Mouse Keratin 6 Isoforms Are Differentially Expressed in the Hair Follicle, Footpad, Tongue, and Activated Epidermis Differentiation · 1999
    10. Human Hair Growth In Vitro Journal of Cell Science · 1990