TLDR Thyrotropin-Releasing Hormone helps heal wounds in frog and human skin.
The document from September 2013 describes a study that demonstrated Thyrotropin-Releasing Hormone (TRH) as a promoter of wound healing in both frog (Xenopus tropicalis) and human skin. The study utilized an ex vivo skin organ culture system and found that TRH significantly stimulated wound closure, keratinocyte proliferation, and the formation of neo-epidermis. In human skin, TRH treatment resulted in increased re-epithelialisation and proliferation, particularly at concentrations of 5 and 10 ng/ml, and up-regulated the expression of cytokeratin 6 (CK6), a marker for wound healing. The study involved 16 frogs and skin samples from 4 human female donors, with the results indicating that TRH is a conserved stimulator of epithelial repair across species. The findings suggest that TRH could be a clinically relevant promoter of wound repair and highlight the value of a comparative biology approach in future wound healing research.
49 citations,
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January 2015 in “Journal of regenerative medicine & tissue engineering” The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.
7 citations,
July 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” Human skin can be reconnected to nerves using stem cells, which may help with skin health and healing.
26 citations,
May 2014 in “BioEssays” Using neurohormones to control keratin can lead to new skin disease treatments.
30 citations,
October 2016 in “Current research in translational medicine” Hair follicles on the scalp interact with and respond to the nervous system, influencing their own behavior and growth.
December 2018 in “IntechOpen eBooks” Neurohormones help control skin health and could treat skin disorders.
