Growth Hormone Operates as a Neuroendocrine Regulator of Human Hair Growth Ex Vivo

    January 2019 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Majid Alam, D. Below, Jérémy Chéret, Ewan A. Langan, Marta Bertolini, Francisco Jiménez, Ralf Paus
    TLDR Growth hormone is important for regulating human hair growth.
    The study demonstrated that growth hormone (GH) acted as a neuroendocrine regulator of human hair follicles (HFs) ex vivo, with GH receptor (GHR) expression confirmed in female human scalp HFs, particularly in the outer root sheath (ORS). Treatment with recombinant GH induced premature catagen development, suggesting GH promotes hair follicle regression through increased expression of transforming growth factor-β2 (TGF-β2), despite also up-regulating insulin-like growth factor 1 (IGF-1). The study analyzed 39-44 HFs from three female donors, highlighting the complex role of GH in hair biology and suggesting potential therapeutic targets for hair growth regulation.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 1000+ results

      community How does hair loss and recovery work?

      in Chat  12 upvotes 3 months ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

      community What happened to that guy who’s been drinking topical minoxidil?!

      in Chat  217 upvotes 1 month ago
      A user tried various hair growth treatments, including drinking topical minoxidil, using oral minoxidil and finasteride, and applying GHK-Cu, growth hormone peptides, and liposomal sulforaphane. They experienced thicker hair, while others discussed the risks and benefits of these methods.

      community M26 - 9 months after hair transplant! AMA

      in Transplants  624 upvotes 5 years ago
      A user who underwent a hair transplant in Istanbul to reduce balding, and the discussion of various treatments such as finasteride and growth hormone for preventing further hair loss.

      community Embraced baldness. Time to leave this subreddit

      in Chat  876 upvotes 4 months ago
      A user shared their positive experience of embracing baldness after years of trying treatments like Minoxidil and finasteride. They found happiness and confidence by shaving their head, despite some social challenges, and encouraged others to focus on their attitude and seek therapy if needed.

      community Finasteride is one of the best decisions I ever made

      in Finasteride/Dutasteride  306 upvotes 1 year ago
      This conversation is about the effectiveness of Finasteride and Minoxidil as treatments for hair loss, with SnooBooks5080 claiming positive results from using both medications. However, other participants in the conversation caution that there are potential side effects to be aware of when taking Finasteride and advise people to do their research before making a decision.

    Similar Research

    5 / 1000+ results