This study found that activation of delta-opioid receptors in keratinocytes may delay the expression of the PER2 gene, suggesting a possible link to cancer development through circadian rhythm disruption.
November 2025 in “The Journal of Immunology” In a murine model of alopecia areata, this study observed that the IL-2 fusion protein HCW9302 helped prevent disease development by expanding regulatory T cells and reducing disease-causing effector T cell infiltrates, suggesting potential for using IL-2 fusion proteins in alopecia areata treatment.
July 2025 in “Journal of Investigative Dermatology” Enhancing Tregs can protect against alopecia areata.
May 2018 in “White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)” In this study, researchers found that alopecia areata patients show a significant reduction in suppressive regulatory T-cells and an increase in inflammatory T-cell populations, suggesting an immunological imbalance contributing to the disease.
May 2021 in “Indian journal of forensic medicine and toxicology” This study reports that teflonpledget-reinforced suturing of coronary fistula, combined with coronary artery bypass grafting, improved symptoms in patients with LAD-to-MPA fistula and triple vessel disease, though larger studies are needed for confirmation.
