Sox18 Promotes the Proliferation of Dermal Papilla Cells via the Wnt/β-Catenin Signaling Pathway

November 2023 in “ International Journal of Molecular Sciences ”

Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun

SOX18 dermal papilla cells Wnt/β-Catenin signaling pathway hair follicles RNA-seq proliferation DPCs Wnt signaling

Studysummary This study observed that SOX18 promotes the proliferation of dermal papilla cells in Hu sheep by activating the Wnt/β-Catenin signaling pathway, suggesting its key role in wool growth. Our plain-language summary of this paper — not a Tressless recommendation.

The study explores the role of the transcription factor SOX18 in the proliferation of dermal papilla cells (DPCs) in Hu sheep, emphasizing its interaction with the Wnt/β-Catenin signaling pathway. It demonstrates that SOX18 overexpression enhances DPC proliferation, while its knockdown reduces it. SOX18 activates the Wnt/β-Catenin pathway, crucial for DPC proliferation and wool growth. RNA-seq analysis identified 246 differentially expressed genes, providing insights into the molecular mechanisms of hair follicle development. The findings suggest that SOX18 could be a potential target for promoting hair growth by modulating the Wnt/β-Catenin pathway.

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