Defining Ovine Dermal Papilla Cell Markers and Identifying Key Signaling Pathways Regulating Its Intrinsic Properties

    February 2023 in “ Frontiers in Veterinary Science
    Shanhe Wang, Tingyan Hu, Mingliang He, Yifei Gu, Xiukai Cao, Zehu Yuan, Xiaoyang Lv, Tesfaye Getachew, Kai Quan, Wei Sun
    TLDR Ovine dermal papilla cells are promising for hair growth research due to their stable properties and hair-inducing abilities.
    This study identifies SOX18 and PDGFRA as novel marker genes for ovine dermal papilla cells (DPCs), which are crucial for hair growth research. Ovine DPCs demonstrate robust and stable aggregation and maintain alkaline phosphatase activity during in vitro culture, suggesting their potential as a superior model for hair growth studies compared to human and murine DPCs. The study highlights the role of Wnt/β-catenin signaling in regulating the intrinsic properties of ovine DPCs, with changes in IGF and FGF signaling pathways also observed. These findings suggest that ovine DPCs could serve as a better seed cell for hair regeneration studies due to their stable aggregation and hair-inducing capabilities.
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