TLDR Scientists created a model using sheep cells to study hair root formation, which can test how different substances affect hair growth.
The document from 2013 details the creation of an in vitro model using sheep dermal papilla cells (DPCs) to study hair follicle dermal papillae morphogenesis. The study demonstrated that these cells can form stable aggregates, mimicking natural dermal papillae behavior, and can be used to measure the effects of compounds on these structures. The researchers found that the cells formed spheroids expressing markers of dermal papillae and established a quantitative assay for aggregate size. They also discovered that lithium chloride reduced aggregate size, while minoxidil counteracted this effect. The model, which remained consistent over multiple cell passages, provides a valuable tool for exploring the regulation of dermal papillae size.
41 citations,
June 2010 in “Journal of Investigative Dermatology” New cells are added to the hair's dermal papilla during the active growth phase.
117 citations,
November 2006 in “Experimental Dermatology” The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.
417 citations,
September 2005 in “PLoS biology” Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.
231 citations,
December 1999 in “Journal of Investigative Dermatology” Hair follicle size is mainly influenced by the number of cells and extracellular matrix volume, with cell number having a larger impact.
3 citations,
January 2019 in “Advances in stem cells and their niches” Dermal papilla cells are key for hair growth and color, influencing hair type and size, and their interaction with stem cells could help treat hair loss and color disorders.
10 citations,
April 2013 in “Journal of Investigative Dermatology” Scientists created a model using sheep cells to study hair root formation, which can test how different substances affect hair growth.
314 citations,
April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
28 citations,
March 2010 in “Histochemistry and cell biology” Skin cells can help create early hair-like structures in lab cultures.
66 citations,
August 2001 in “Experimental Dermatology” Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
65 citations,
October 1988 in “Clinics in dermatology” The dermal papilla interacts with the epidermis to control hair growth and development.
