CRABP2 Promotes the Proliferation of Dermal Papilla Cells via the Wnt/Beta-Catenin Pathway

    June 2023 in “ Animals ”
    Ming‐Liang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Kai Quan, Tesfaye Getachew, Joram M. Mwacharo, Aynalem Haile, Yutao Li, Shanhe Wang, Wei Sun
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    TLDR CRABP2 helps increase the growth of cells important for hair growth by activating a specific growth pathway.
    The research "CRABP2 Promotes the Proliferation of Dermal Papilla Cells via the Wnt/β-Catenin Pathway" demonstrates that the CRABP2 gene plays a significant role in the proliferation of dermal papilla cells (DPCs), which are crucial for hair follicle growth. Overexpression of CRABP2 increased DPC proliferation and activated the Wnt/β-catenin pathway, a key pathway for cell growth. The study also found that CRABP2 could rescue the activation of the Wnt/β-catenin pathway when it was inhibited, suggesting its potential as a target for hair growth treatments. The findings were statistically significant with a sample size of 3 for each test.
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