Effect of CUX1 on the Proliferation of Hu Sheep Dermal Papilla Cells and on the Wnt/β-Catenin Signaling Pathway

    February 2023 in “ Genes
    Hui Zhou, Sainan Huang, Xiaoyang Lv, Shanhe Wang, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Joram M. Mwacharo, Aynalem Haile, Kai Quan, Yutao Li, Antônio Reverter, Wei Sun
    TLDR CUX1 boosts sheep hair cell growth and affects curl patterns.
    The study explores the role of CUX1 in the proliferation of Hu sheep dermal papilla cells (DPCs) and its effect on the Wnt/β-catenin signaling pathway, which is essential for hair follicle growth. By manipulating CUX1 expression, researchers found that overexpression of CUX1 enhanced DPC proliferation and increased the expression of genes like MMP7 and CCND1, while knockdown had the opposite effect. These results indicate that CUX1 significantly influences hair follicle development and could affect lambskin curl patterns by modulating the Wnt/β-catenin pathway.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    0 / 0 results
    — no results

    Related Research

    1 / 1 results