Decision Letter: ETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas
October 2015
TLDR ETS2 drives cancer progression in squamous cell carcinoma and is linked to poor patient outcomes.
The study explored the role of ETS family transcriptional regulators in squamous cell carcinomas (SCCs), focusing on their interaction with super enhancers (SEs). Researchers found that ETS transcription factors, particularly ETS2, were regulated by SEs specific to SCCs, contributing to tumor dynamics by upregulating SE-regulated genes and maintaining cancer stem cell-specific SEs. Despite some limitations, such as the lack of genome-wide data, the study provided evidence of ETS2's binding to SE epicenters and its influence on chromatin dynamics, highlighting its importance in SCC development, including hyperproliferation and inflammatory cell recruitment. Reviewers suggested further experiments to strengthen the claims regarding SE dynamics and ETS factor involvement.
