Author Response: ETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas
November 2015
TLDR ETS2 is crucial in squamous cell carcinoma development and could be a therapeutic target.
The study investigated the role of ETS family transcriptional regulators in squamous cell carcinomas (SCCs), focusing on their regulation by super enhancers. It found that the super-activated form of ETS2 induced a phenotype and expression profile similar to SCCs, with upregulation of genes like Cxcl1, Cxcl2, and Elk3. The study showed that 50% of genes upregulated by ETS superactivation were also upregulated in SCC stem cells. Although there was a lack of direct evidence linking ETS factors to super enhancer regulation, the authors demonstrated ETS2 binding to super enhancer epicenters and its overexpression led to hyperproliferation and increased inflammatory cell recruitment, suggesting its role in chromatin dynamics and cancer progression. Reviewers recommended further experiments to substantiate these claims.
