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Glossary cAMP response element-binding protein

regulates gene transcription in response to cellular signals

cAMP response element-binding protein (CREB) is a cellular protein that binds to specific DNA sequences called cAMP response elements, thereby regulating the transcription of certain genes. It plays a crucial role in various cellular processes, including the growth and survival of cells, by responding to hormonal signals and other external stimuli.

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research 126 cAMP response element-binding protein 1 (CREB) is a β-catenin-regulated transcription factor in squamous cell carcinoma (SCC) cells

April 2018 in “Journal of Investigative Dermatology”

This study observed that β-catenin overexpression in human squamous cell carcinoma cells led to increased CREB expression, which significantly enhanced clonogenic activity, suggesting CREB as a β-catenin-regulated factor promoting cancer characteristics.

The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

research The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

72 citations , January 2003 in “American Journal of Pathology”

This study found that the co-activator CBP enhances the agonistic action of hydroxyflutamide on androgen receptors, suggesting a mechanism for therapy resistance in prostate cancer.

research Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport

December 2023 in “Journal of ethnopharmacology”

This study found that tribuloside, a flavonoid from Tribulus terrestris L., enhances melanin production in human melanocytes, zebrafish, and human skin samples without causing toxicity, potentially through inhibiting PDE to increase cAMP levels and promote the melanin biosynthesis pathway.

Chromatin Architectural Protein CTCF Controls Epidermal Barrier Formation, Hair Follicle Fate Maintenance, and Suppresses Inflammatory Responses in the Skin Epithelium

research 874 Chromatin architectural protein CTCF controls epidermal barrier formation, hair follicle fate maintenance and suppresses inflammatory responses in the skin epithelium

April 2017 in “Journal of Investigative Dermatology”

In this study, CTCF was found to play essential roles in epidermal differentiation and skin barrier formation, simultaneously acting as a suppressor of epithelial inflammatory responses in mouse skin.

research Nerve growth factor regulates the proliferation of cashmere goat outer root sheath cells through the activation of cAMP-binding protein

1 citations , July 2019 in “Small ruminant research”

This study suggests that the NGF/TrkA/CREB system plays a crucial role in promoting outer root sheath cell proliferation in cashmere goats, which may aid in marker-assisted breeding.

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community So what’s really the deal with dutasteride hairline ruining claims?

in Finasteride/Dutasteride 72 upvotes 3 years ago

The potential effects of dutasteride on hair loss, with some users reporting it improved their hairline while others experienced worsened hair loss or shedding. Other treatments discussed include minoxidil and finasteride, as well as RU58841.

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Corie Camp
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