MmuPV1-Induced Cutaneous Squamous Cell Carcinoma Arises Preferentially from Lgr5+ Epithelial Progenitor Cells

    August 2022 in “ Viruses ”
    Ruben Moreno, Darya Buehler, Paul F. Lambert
    Studysummary This study found that cutaneous squamous cell carcinomas in mice infected with murine papillomavirus preferentially arise from Lgr5+ progenitor cells, while squamous cell dysplasia does not.
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    Research cited in this study 10

    1. Quiescent Tissue Stem Cells Evade Immune Surveillance Immunity · 2018
    2. NF-κB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in Various Pelage Hair Follicle Types ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2017
    3. HPV8 Field Cancerization in a Transgenic Mouse Model Is Due to Lrig1+ Keratinocyte Stem Cell Expansion Journal of Investigative Dermatology · 2017
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    5. The HPV16 Oncogenes Cause Aberrant Stem Cell Mobilization Virology · 2013
    6. Epithelial Stem Cells And Implications For Wound Repair Seminars in Cell & Developmental Biology · 2012
    7. Progeny of Lgr5-Expressing Hair Follicle Stem Cell Contributes to Papillomavirus-Induced Tumor Development in Epidermis Oncogene · 2012
    8. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    9. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    10. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001