MmuPV1-Induced Cutaneous Squamous Cell Carcinoma Arises Preferentially from Lgr5+ Epithelial Progenitor Cells

    August 2022 in “ Viruses ”
    Ruben Moreno, Darya Buehler, Paul F. Lambert
    TLDR Skin cancer often starts from Lgr5+ progenitor cells.
    The study investigates the role of Lgr5+ epithelial progenitor cells in the development of cutaneous squamous cell carcinoma (cSCC) induced by murine papillomavirus (MmuPV1) in mice. Using lineage tracing with Lgr5-eGFP-IRES-CreERT2/Rosa26LSLtdTomato mice, the researchers found that cSCC lesions had a significantly higher percentage of tdTomato+ cells (42%) compared to squamous dysplasia (7%), indicating that cSCCs preferentially arise from Lgr5+ progenitor cells. This suggests that Lgr5+ cells play a crucial role in the pathogenesis of MmuPV1-induced cSCC. Additionally, increased Sox9 and phospho-S6 expression were observed in cSCC, further characterizing the molecular environment of these tumors.
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