169 citations
,
February 2018 in “Immunity” Inactive stem cells in hair follicles and muscles can avoid detection by the immune system.
23 citations
,
September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” NF-κB is crucial for different stages and types of hair growth in mice.
25 citations
,
June 2017 in “Journal of Investigative Dermatology” The study investigated the role of hair follicle (HF) keratinocyte stem cells in β-HPV-induced skin carcinogenesis using a transgenic mouse model expressing the HPV8 early region. The HPV8 transgenic mice exhibited thicker skin and a hyperproliferative epidermis compared to wild-type mice. Notably, there was a significant proliferation of Lrig1+ keratinocyte stem cells, with a 2.8-fold expansion and a 3.8-fold increase in colony-forming efficiency, while other stem cell populations did not show similar proliferation. This proliferation was linked to nuclear p63 expression and a switch to ΔNp63 isoforms. The findings suggested that β-HPV field cancerization originated from the HF junctional zone, potentially leading to squamous cell carcinoma.
23 citations
,
May 2013 in “Virology” HPV16 oncogenes disrupt the normal activity of hair follicle stem cells.
156 citations
,
October 2012 in “Seminars in Cell & Developmental Biology” Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.
52 citations
,
September 2012 in “Oncogene” 
759 citations
,
February 2009 in “Current Biology” Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
835 citations
,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
949 citations
,
January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
