Protein Kinase C Epsilon, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells

    January 2013 in “ Journal of skin cancer ”
    Ashok K. Singh, Anupama Singh, Jordan M. Sand, Erika Héninger, Bilal Bin Hafeez, Ajit Kumar Verma
    Image of study
    TLDR PKC ε increases hair follicle stem cell turnover and may raise skin cancer risk.
    The study investigated the role of protein kinase C epsilon (PKC ε) in UV radiation-induced squamous cell carcinomas (SCC) by comparing PKC ε transgenic (TG) mice with wild-type (WT) mice. It was found that UVR exposure increased the frequency of hair follicle stem cells (HSCs) in TG mice compared to WT mice. Additionally, TG mice showed a significant decrease in the retention of BrdU label in HSCs, indicating a higher turnover rate. Gene expression analysis revealed increased expression of Pes1, Rad21, Tfdp1, and Cks1b in TG mice. PKC ε overexpression also enhanced the clonogenicity of keratinocytes, suggesting a link between PKC ε and increased stem cell activity and susceptibility to SCC.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 494 results

      community Natural Remedies: Polyphenols and Hair Loss

       19 upvotes 5 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

      community Helicobacter's concocted serum v1

       7 upvotes 5 years ago
      A custom-made serum based on double-blind studies for AGA, which includes natural ingredients such as rosemary oil, procyanidin B-2, saw palmetto extract, curcuma aeruginosa, pumpkin seed oil and castor oil. The user has updated their recipe to include apple poly procyanidin B-2 4% concentration and other ingredients before topping it off with Pura d'or serum.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Vegan Protein Powder Make Loss Worse?

      in Female  2 upvotes 3 months ago
      A user is experiencing genetic hair loss and is using spironolactone and minoxidil without success. They are considering switching to vegan protein powder due to digestive issues and are concerned if it will worsen hair loss.

      community Does whey protein and creatine aggravate hair loss?

      in Research/Science  82 upvotes 11 months ago
      The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.

    Similar Research

    5 / 1000+ results