Protein Kinase C Epsilon, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells

    January 2013 in “ Journal of skin cancer ”
    Ashok K. Singh, Anupama Singh, Jordan M. Sand, Erika Héninger, Bilal Bin Hafeez, Ajit Kumar Verma
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    TLDR PKC ε increases hair follicle stem cell turnover and may raise skin cancer risk.
    The study investigated the role of protein kinase C epsilon (PKC ε) in UV radiation-induced squamous cell carcinomas (SCC) by comparing PKC ε transgenic (TG) mice with wild-type (WT) mice. It was found that UVR exposure increased the frequency of hair follicle stem cells (HSCs) in TG mice compared to WT mice. Additionally, TG mice showed a significant decrease in the retention of BrdU label in HSCs, indicating a higher turnover rate. Gene expression analysis revealed increased expression of Pes1, Rad21, Tfdp1, and Cks1b in TG mice. PKC ε overexpression also enhanced the clonogenicity of keratinocytes, suggesting a link between PKC ε and increased stem cell activity and susceptibility to SCC.
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