Data from Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin
March 2023
Studysummary This study found that selective inactivation of ribonucleotide excision repair in mouse epidermis led to spontaneous DNA damage, skin inflammation, and the development of squamous cell carcinoma, suggesting potential implications for cancer development in humans.
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The study demonstrates that selective inactivation of ribonucleotide excision repair (RER) in mouse epidermis leads to spontaneous DNA damage, epidermal hyperproliferation, loss of hair follicle stem cells, and hair follicle function. This condition results in the development of keratinocyte intraepithelial neoplasia and invasive squamous cell carcinoma with complete penetrance, despite a strong type I interferon response and skin inflammation. These findings suggest that impairments in RER-mediated genome maintenance could be a significant factor in promoting tumor development in human cancer.
