Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis

The document reviewed the development and applications of Bioengineered Artificial Skin Substitutes (BASS) as in vitro models for pharmacosmetics, skin disease studies, and environmental impact analysis. BASS evolved from replacing skin grafts to becoming essential in reducing animal testing and advancing research in cosmetics and pharmacology. The models emulated skin functions, aiding in disease modeling and pharmaceutical screening, despite challenges like replicating complex cell interactions. Advances in tissue engineering, such as three-dimensional models and bio-printing, improved their relevance and applicability. The study emphasized the importance of good manufacturing practices and collaborative efforts in enhancing these models' functionality and reliability.