Future Horizons in Hair Restoration
August 2013
in “
Facial Plastic Surgery Clinics of North America
”
cell-based therapies androgenetic alopecia hair transplantation stem cell biology regenerative medicine hair follicle cells in vitro re-implanting clinical trials Aderans Research Institute Replicel Life Sciences hair follicle regeneration epidermal cells dermal papilla cells induced pluripotent stem cells iPSCs human scalp model hair loss hair restoration hair transplant stem cells regenerative treatment hair cells lab-grown re-implant clinical studies Aderans Replicel hair regrowth skin cells hair root cells pluripotent stem cells iPS cells scalp model
TLDR New cell-based therapies may improve hair loss treatments in the future.
The document from August 2013 reviews the potential of cell-based therapies for hair restoration, with a focus on treating androgenetic alopecia. It discusses the limitations of current hair transplantation and medical treatments, which have drawbacks such as a limited number of donor follicles and side effects. The article highlights advances in stem cell biology and regenerative medicine that could lead to new hair loss treatments, such as expanding hair follicle cells in vitro and then re-implanting them. It mentions clinical trials by Aderans Research Institute and Replicel Life Sciences. The document also discusses the history and challenges of hair follicle regeneration, the role of epidermal cells, and the first successful creation of human hair from cultured dermal papilla cells. Induced pluripotent stem cells (iPSCs) are recognized for their potential in hair follicle formation, and the document stresses the importance of developing a clinically relevant model of the human scalp to advance these therapies.
