35 citations
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January 2020 in “Skin Pharmacology and Physiology” This review discusses the biology and signaling mechanisms of dermal papilla cells in hair follicle growth and reports no new clinical results; the authors emphasize the importance of optimizing culture conditions for hair restoration.
1 citations
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July 2025 in “Biomaterials Advances” This study investigated how 2D and 3D cell culturing methods influence hair follicle morphogenesis, finding that 3D cultures responded more expectedly to minoxidil while 2D cultures reacted better to DHT treatment, challenging the assumption that 3D cultures are always superior.
31 citations
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August 2019 in “Regenerative Medicine” This study found that the human placenta extracellular matrix hydrogel restored the hair-inductive capacity of high-passaged dermal papilla cells, enabling them to regenerate new hair follicles when co-grafted with mouse epidermal cells.
18 citations
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November 2013 in “Molecules and Cells” This study found that a novel 3D in vitro culture condition improved stemness markers and proliferation potential in human dermal stem/progenitor cells compared to traditional 2D methods.
In this study, researchers optimized the culture strategy for dermal papilla cells and established a promising immortalized cell strain, iDP6, which resembles primary DP cells and is suitable for further research applications.
