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research Dihydrotestosterone induces p27 degradation via direct binding with SKP2 in ovarian and breast cancer

18 citations , April 2011 in “International Journal of Molecular Medicine”

This study found that dihydrotestosterone (DHT) regulates the degradation of p27 in MCF-7 breast cancer and OVCAR-3 ovarian cancer cells, involving SKP2 as a key factor.

research Proteolysis‐targeting chimeras in cancer therapy: Targeted protein degradation for next‐generation treatment

3 citations , October 2025 in “Cancer”

This review highlights the potential of PROTACs to transform cancer treatment by selectively degrading oncogenic proteins, overcoming drug resistance, and reducing toxicity; it also discusses challenges in optimizing these therapies for personalized applications.

research Hydroxyl radical mediates cisplatin-induced apoptosis in human hair follicle dermal papilla cells and keratinocytes through Bcl-2-dependent mechanism

52 citations , May 2011 in “APOPTOSIS”

In this study, cisplatin was found to induce cell death in human hair follicle cells through hydroxyl radical generation and Bcl-2 down-regulation, suggesting potential strategies for preventing chemotherapy-induced alopecia.

research Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus

13 citations , January 2020 in “Scientific Reports”

This study found distinct differences in protein expression and wound healing pathways between Acomys cahirinus and Mus musculus, highlighting potential targets for reducing fibrotic response in mammals.

research Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future Directions

9 citations , October 2025 in “MedComm”

This review discusses the development and clinical progression of PROTAC technology for targeted protein degradation, highlighting its potential to address previously "undruggable" targets but reports no new clinical results.

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community GT20029 Will Replace Finasteride For Hair Loss

58 upvotes 4 months ago

GT20029 shows promise as a topical treatment for hair loss, potentially replacing finasteride for some due to its low systemic exposure and ability to degrade androgen receptors. However, skepticism remains about its long-term efficacy and availability, with some users expressing doubt about new treatments consistently failing to reach the market.

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