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research Hydroxyl Radical Mediates Cisplatin-Induced Apoptosis in Human Hair Follicle Dermal Papilla Cells and Keratinocytes Through Bcl-2-Dependent Mechanism

52 citations, May 2011 in “APOPTOSIS”

Hydroxyl radicals cause hair follicle cell death during chemotherapy by reducing Bcl-2 protein levels.

research Protein Degradation: Expanding the Toolbox to Restrain Cancer Drug Resistance

7 citations, January 2023 in “Journal of Hematology & Oncology”

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

research Scoparone Induces Expression of Pluripotency Transcription Factors SOX2 and NANOG in Dermal Papilla Cells

4 citations, January 2021 in “in Vivo”

Scoparone may help stimulate hair growth by increasing stem cell-related proteins in skin cells.

research Insight into Recent Advances in Degrading Androgen Receptor for Castration-Resistant Prostate Cancer

February 2024 in “Cancers”

New treatments targeting androgen receptors show promise for drug-resistant prostate cancer.

research Signaling Pathways and Targeted Therapeutic Strategies for Polycystic Ovary Syndrome

October 2023 in “Frontiers in endocrinology”

Effective PCOS treatments require targeting specific signaling pathways.

View more "ubiquitin-proteasomal degradation" in research →

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community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 134 upvotes 10 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 122 upvotes 1 year ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.