Proteolysis-Targeting Chimeras in Cancer Therapy: Targeted Protein Degradation for Next-Generation Treatment

    October 2025 in “ Cancer ”
    Yanett Anaya, Marilyn Barragan, Ricardo Pequeno Bracho … Manish K. Tripathi
    Studysummary This review highlights the potential of PROTACs to transform cancer treatment by selectively degrading oncogenic proteins, overcoming drug resistance, and reducing toxicity; it also discusses challenges in optimizing these therapies for personalized applications.
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    Research cited in this study 2

    1. Insight into Recent Advances in Degrading Androgen Receptor for Castration-Resistant Prostate Cancer Cancers · 2024
    2. What's New in Therapy for Male Androgenetic Alopecia? American Journal of Clinical Dermatology · 2022