Glycogen Phosphorylase Inhibitor Promotes Hair Growth via Protecting from Oxidative Stress and Regulating Glycogen Breakdown in Human Hair Follicles

August 2024 in “ Biomolecules & Therapeutics ”

Eun‐Cheol Park, Daeun Kim, Hairu Zhao, SoonRe Kim, Byung Cheol Park, Sanghwa Lee, Yurim Lee, Hee Dong Park, Dongchul Lim, S. Ryu, Jae Sung Hwang

glycogen phosphorylase inhibitor Hydroxytrimethylpyridinyl Methylindolecarboxamide HTPI hair growth oxidative stress human dermal papilla cells hDPCs glycogen breakdown human outer root sheath cells hORSCs anagen marker ALP levels glucose starvation ex-vivo culture minoxidil Rogaine

TLDR A new compound, HTPI, promotes hair growth by protecting cells from damage and regulating energy use.

The study developed a new glycogen phosphorylase inhibitor, Hydroxytrimethylpyridinyl Methylindolecarboxamide (HTPI), to promote hair growth by protecting human dermal papilla cells (hDPCs) from oxidative stress and regulating glycogen breakdown in human outer root sheath cells (hORSCs). HTPI reduced oxidative damage, prevented cell death, restored anagen marker ALP levels in hDPCs, inhibited glycogen degradation, and induced cell survival under glucose starvation in hORSCs. In ex-vivo culture, HTPI significantly enhanced hair growth, showing results comparable to minoxidil, suggesting its potential as a therapeutic agent for hair loss prevention and treatment.

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