Hibiscus Rosa Sinensis Linn. Petals Modulate Glycogen Metabolism and Glucose Homeostasis Signaling Pathway in Streptozotocin-Induced Experimental Diabetes
November 2015
in “
Plant Foods for Human Nutrition
”
Hibiscus rosa sinensis ethyl acetate fraction streptozotocin serum glucose glycated haemoglobin metformin liver enzyme levels glycogen content glucose homeostasis gene expressions histopathological analysis liver architecture pancreas architecture nutraceutical Hibiscus EHRS blood sugar HbA1c liver enzymes blood sugar regulation gene expression liver structure pancreas structure dietary supplement
TLDR Hibiscus petals helped control blood sugar and improve liver and pancreas health in diabetic rats.
The study from 2015 examined the effects of the ethyl acetate fraction of Hibiscus rosa sinensis Linn. petals (EHRS) on diabetic rats induced by streptozotocin. It was found that EHRS, at a dose of 25 mg/kg body weight, significantly reduced serum glucose and glycated haemoglobin levels, comparable to the effects of the anti-diabetic drug metformin. EHRS also normalized liver enzyme levels, restored glycogen content, and modulated gene expressions related to glucose homeostasis. Histopathological analysis confirmed the preservation of liver and pancreas architecture. The study, which included 6 rats per group, concluded that EHRS could be a potential nutraceutical for managing diabetes.
