learn Dutasteride
Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity
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learn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
learn Neem Oil
natural substance from Neem tree with medicinal and pesticidal properties
learn Cyproterone
a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
Research
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research Ingestion of Minoxidil Associated with Elevated Transaminases in the Absence of Ischemic Hepatitis
Minoxidil ingestion can raise liver enzyme levels.
research Single Nucleotide Polymorphisms Associated with Elevated Alanine Aminotransferase in Patients Receiving Asunaprevir Plus Daclatasvir Combination Therapy for Chronic Hepatitis C
Certain genetic variations are linked to higher liver enzyme levels in patients treated for chronic hepatitis C with specific drugs.
research Efficacy and Adverse Effects of Oral Janus Kinase Inhibitor Use in Patients With Lichen Planopilaris: A Retrospective Case Series and Systematic Review
Oral Janus kinase inhibitors may be an effective treatment option for lichen planopilaris with some risk of increased cholesterol and liver enzyme levels.
research Hepatotoxicity with Low- and Ultralow-Dose Flutamide: A Surveillance Study on 203 Hyperandrogenic Young Females
Low and ultralow doses of flutamide can cause liver damage in young women with high androgen levels, regardless of dose or birth control use, with higher risk for those with higher BMI and liver enzyme levels before treatment.
research Hibiscus Rosa Sinensis Linn. Petals Modulate Glycogen Metabolism and Glucose Homeostasis Signaling Pathway in Streptozotocin-Induced Experimental Diabetes
Hibiscus petals helped control blood sugar and improve liver and pancreas health in diabetic rats.
Community Join
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community M27 Fin/Min (topical) was fun while it lasted
The user experienced significant hair regrowth using topical Minoxidil and Finasteride but had to stop due to high liver enzyme levels. They plan to pause treatment for a month to see if their liver values return to normal.
community 1.5yrs topical min & keto shampoo, 10 months fin, ~3 months dut
The user shared progress on hair regrowth using 5% topical minoxidil, 2% keto shampoo, oral finasteride, and recently switched to daily dutasteride. They reported positive results without significant side effects and are hopeful for further improvement.
community Dutasteride High Libido. How come we don't talk about this?
Dutasteride and finasteride can affect libido differently, with some experiencing increased libido and others decreased libido or erectile dysfunction. Dutasteride may increase testosterone levels but can also cause side effects like liver enzyme changes, while topical finasteride may have fewer sexual side effects.
community 5ARI (dutasteride) Associated with Adverse Metabolic Effects
Dutasteride is associated with increased blood glucose, HbA1c, LDL cholesterol, and liver enzyme activity, potentially leading to diabetes, NAFLD, and liver metabolism changes. The conversation highlights concerns about these adverse effects and calls for more studies, including on finasteride.
community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism
Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.